儿童肥胖与阻塞性睡眠呼吸暂停相关性的研究进展
[Research progress on correlation between childhood obesity and obstructive sleep apnea].
作者信息
Li Jing, Yang Quyang, Xu Ying, Han Fugen, Zhao Jing
机构信息
Department of Otolaryngology Head and Neck Surgery，Children's Hospital Affiliated of Zhengzhou University，Henan Children's Hospital，Zhengzhou Children's Hospital，Zhengzhou，450000，China.
Department of Otolaryngology Head and Neck Surgery，Beijing Children's Hospital，Capital Medical University，National Children's Medical Center.
出版信息
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2023 Apr;37(4):318-322. doi: 10.13201/j.issn.2096-7993.2023.04.017.
Prevalence of childhood obesity is progressively increasing, reaching worldwide levels of 5.6% in girls and of 7.8% in boys. This also leads to a corresponding increase in the prevalence of obesity-associated morbidities particularly those involving obstructive sleep apnea（OSA）. Obesity is an independent risk factor and regulator of OSA in children. There is a bidirectional causal relationship between OSA and obesity in children. The factors involved in the association between OSA and obesity are systemic inflammation, oxidative stress, and gut microbiota etc. However, a causal link between obesity-related inflammatory state and OSA pathogenesis still needs to be properly confirmed. The present review aimed to investigate the links between childhood obesity and OSA.
儿童肥胖症的患病率正在逐步上升，在全球范围内，女孩的患病率达到5.6%，男孩的患病率达到7.8%。这也导致肥胖相关疾病的患病率相应增加，尤其是那些涉及阻塞性睡眠呼吸暂停（OSA）的疾病。肥胖是儿童OSA的独立危险因素和调节因素。儿童OSA与肥胖之间存在双向因果关系。OSA与肥胖之间关联的因素包括全身炎症、氧化应激和肠道微生物群等。然而，肥胖相关炎症状态与OSA发病机制之间的因果联系仍需得到恰当证实。本综述旨在研究儿童肥胖与OSA之间的联系。
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