Tran Nhan Hau, Shtam Tatiana, Marchenko Yaroslav Yu, Konevega Andrey L, Lebedev Dmitry
Petersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Centre «Kurchatov Institute», Orlova roscha 1, Gatchina 188300, Russia.
Institute of Biomedical Systems and Biotechnology, Peter the Great St. Petersburg Polytechnic University, Politehnicheskaya 29, St. Petersburg 195251, Russia.
Biomedicines. 2023 Jun 16;11(6):1727. doi: 10.3390/biomedicines11061727.
The development of new methods increasing the biological effectiveness of proton therapy (PT) is of high interest in radiation oncology. The use of binary technologies, in which the damaging effect of proton radiation is further enhanced by the selective accumulation of the radiosensitizer in the target tissue, can significantly increase the effectiveness of radiation therapy. To increase the absorbed dose in a tumor target, proton boron capture therapy (PBCT) was proposed based on the reaction of proton capture on the B isotope with the formation of three α-particles. This review summarizes data on theoretical and experimental studies on the effectiveness and prospects of proton boron capture therapy.
开发提高质子治疗（PT）生物有效性的新方法在放射肿瘤学中备受关注。使用二元技术，即通过放射增敏剂在靶组织中的选择性积累进一步增强质子辐射的损伤作用，可显著提高放射治疗的有效性。为了增加肿瘤靶区的吸收剂量，基于质子与硼同位素捕获反应生成三个α粒子，提出了质子硼俘获治疗（PBCT）。本文综述了关于质子硼俘获治疗有效性和前景的理论与实验研究数据。
