Suppr超能文献

《速度与激情：快中子疗法在癌症治疗中的应用》

Fast and Furious: Fast Neutron Therapy in Cancer Treatment.

作者信息

Gordon Konstantin, Gulidov Igor, Fatkhudinov Timur, Koryakin Sergey, Kaprin Andrey

机构信息

Federal State Autonomous Educational Institution of Higher Education "People's Friendship University of Russia," Medical Institution, Moscow, Russia.

A. Tsyb Medical Radiological Research Center-branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Obninsk, Russia.

出版信息

Int J Part Ther. 2022 Aug 5;9(2):59-69. doi: 10.14338/IJPT-22-00017. eCollection 2022 Fall.

DOI:10.14338/IJPT-22-00017
PMID:36060415
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9415749/
Abstract

Fast neutron therapy has been used for decades. In conjunction with recent advances in photonic techniques, fast neutrons are no longer of much oncologic interest, which is not unequivocally positive, given their undoubted therapeutic value. This mini-review recalls the history of medical research on fast neutrons, considers their physical and radiobiological properties alongside their benefits for cancer treatment, and discusses their place in modern radiation oncology.

摘要

快中子疗法已经应用了数十年。随着光子技术的最新进展，快中子在肿瘤学方面已不再具有太大的研究价值，尽管其治疗价值毋庸置疑，但这并非绝对是好事。这篇小型综述回顾了快中子医学研究的历史，探讨了其物理和放射生物学特性以及在癌症治疗中的优势，并讨论了它们在现代放射肿瘤学中的地位。

相似文献

1
Fast and Furious: Fast Neutron Therapy in Cancer Treatment.《速度与激情：快中子疗法在癌症治疗中的应用》
Int J Part Ther. 2022 Aug 5;9(2):59-69. doi: 10.14338/IJPT-22-00017. eCollection 2022 Fall.
2
Present status, trends and needs in fast neutron therapy.快中子治疗的现状、趋势与需求
Bull Cancer Radiother. 1996;83 Suppl:68s-77s. doi: 10.1016/0924-4212(96)84888-2.
3
Review of clinical results of fast neutron therapy in the USA.美国快中子治疗的临床结果综述。
Strahlentherapie. 1985 Dec;161(12):731-8.
4
Biological factors influencing the RBE of neutrons: implications for their past, present and future use in radiotherapy.
Radiat Res. 2001 Aug;156(2):125-35. doi: 10.1667/0033-7587(2001)156[0125:bfitro]2.0.co;2.
5
Relative biological effectiveness of neutrons for cancer induction and other late effects: a review of radiobiological data.中子诱发癌症及其他晚期效应的相对生物学效能：放射生物学数据综述
Recent Results Cancer Res. 1998;150:54-87. doi: 10.1007/978-3-642-78774-4_3.
6
The influence of hypoxia on the relative sensitivity of human tumor cells to 62.5 MeV (p-->Be) fast neutrons and 4 MeV photons.缺氧对人肿瘤细胞对62.5兆电子伏（质子束轰击铍）快中子和4兆电子伏光子相对敏感性的影响。
Radiat Res. 2000 Jul;154(1):54-63. doi: 10.1667/0033-7587(2000)154[0054:tiohot]2.0.co;2.
7
Prospects for the application of fast neutrons in cancer therapy. Radiobiological bases and survey of the clinical data.快中子在癌症治疗中的应用前景。放射生物学基础及临床数据综述。
Bull Cancer. 1986;73(5):546-61.
8
Basic radiobiological investigations of fast neutrons.快中子的基础放射生物学研究
Radiat Res. 1991 Oct;128(1 Suppl):S94-102.
9
A radiobiological basis for setting neutron radiation safety standards.
Health Phys. 1985 Nov;49(5):883-96. doi: 10.1097/00004032-198511000-00020.
10
Fast neutron therapy for malignant astrocytomas. A review.
J Neurooncol. 1986;4(2):123-9. doi: 10.1007/BF00165372.

引用本文的文献

1
3D Measurement of Neutron-Induced Tracks Using Confocal Microscopy.使用共聚焦显微镜对中子诱导径迹进行三维测量。
Sensors (Basel). 2025 Aug 23;25(17):5256. doi: 10.3390/s25175256.
2
An Overview of Head and Neck Tumor Reirradiation: What Has Been Achieved So Far?头颈部肿瘤再程放疗概述：目前已取得哪些成果？
Cancers (Basel). 2023 Sep 4;15(17):4409. doi: 10.3390/cancers15174409.
3
Current State and Prospectives for Proton Boron Capture Therapy.质子硼俘获疗法的现状与展望
Biomedicines. 2023 Jun 16;11(6):1727. doi: 10.3390/biomedicines11061727.
4
Photon- and Proton-Mediated Biological Effects: What Has Been Learned?光子和质子介导的生物学效应：我们了解到了什么？
Life (Basel). 2022 Dec 22;13(1):30. doi: 10.3390/life13010030.

本文引用的文献

1
Comparisons of 3-Dimensional Conformal and Intensity-Modulated Neutron Therapy for Head and Neck Cancers.头颈部癌三维适形与调强中子治疗的比较。
Int J Part Ther. 2021 Sep 14;8(2):51-61. doi: 10.14338/IJPT-20-00059.1. eCollection 2021 Fall.
2
Clinical Radiobiology of Fast Neutron Therapy: What Was Learnt?快中子治疗的临床放射生物学：学到了什么？
Front Oncol. 2020 Sep 15;10:1537. doi: 10.3389/fonc.2020.01537. eCollection 2020.
3
[Not Available].
Ber Wiss. 2017 Dec;40(4):368-392. doi: 10.1002/bewi.201701871.
4
A portable fast neutron irradiation system for tumor therapy.一种用于肿瘤治疗的便携式快中子辐照系统。
Appl Radiat Isot. 2020 Jun;160:109138. doi: 10.1016/j.apradiso.2020.109138. Epub 2020 Mar 21.
5
Does Neutron Radiation Therapy Potentiate an Immune Response to Merkel Cell Carcinoma?中子放射治疗能否增强对默克尔细胞癌的免疫反应？
Int J Part Ther. 2018 Summer;5(1):183-195. doi: 10.14338/IJPT-18-00012.1. Epub 2018 Sep 21.
6
Neutron Radiation Therapy for Treatment of Refractory Merkel Cell Carcinoma.中子放射治疗难治性默克尔细胞癌
Int J Part Ther. 2017 Spring;3(4):485-491. doi: 10.14338/IJPT-17-00003.1. Epub 2017 Jul 11.
7
Neutrons are forever! Historical perspectives.中子是永恒的！历史透视。
Int J Radiat Biol. 2019 Jul;95(7):957-984. doi: 10.1080/09553002.2019.1569782. Epub 2019 Feb 13.
8
The efficacy of neutron radiation therapy in treating salivary gland malignancies.中子辐射疗法治疗唾液腺癌的疗效。
Oral Oncol. 2019 Jan;88:51-57. doi: 10.1016/j.oraloncology.2018.11.006. Epub 2018 Nov 21.
9
Proton beam therapy in Europe: more centres need more research.欧洲的质子束治疗：更多的中心需要更多的研究。
Br J Cancer. 2019 Apr;120(8):777-778. doi: 10.1038/s41416-018-0329-x. Epub 2018 Dec 11.
10
Dosimetric characteristics of the University of Washington Clinical Neutron Therapy System.华盛顿大学临床中子治疗系统的剂量学特性。
Phys Med Biol. 2018 May 15;63(10):105008. doi: 10.1088/1361-6560/aabd52.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验