Nuncio-Mora Lucero, Lanzagorta Nuria, Nicolini Humberto, Sarmiento Emmanuel, Ortiz Galo, Sosa Fernanda, Genis-Mendoza Alma Delia
Laboratory of Genomics of Psychiatric and Neurodegenerative Diseases, National Institute of Genomic Medicine, Mexico City 14610, Mexico.
Posgraduate Studies in Biological Sciences, Posgraduate Unit, Posgraduate Circuit, Universitary City, Building D, 1st Floor, Coyoacan, Mexico City 04510, Mexico.
Biomedicines. 2023 Jun 20;11(6):1770. doi: 10.3390/biomedicines11061770.
The relationship between the gut-brain-microbiome axis has gained great importance in the study of psychiatric disorders, as it may represent a new target for their treatment. To date, the available literature suggests that the microbiota may influence the pathophysiology of several diseases, including psychosis. The aim of this review is to summarize the clinical and preclinical studies that have evaluated the differences in microbiota as well as the metabolic consequences related to psychosis. Current data suggest that the genera and are increased in schizophrenia (SZ), as well as alterations in the glutamate-glutamine-GABA cycle, serum levels of tryptophan, kynurenic acid (KYNA), and short-chain fatty acids (SCFAs). There are still very few studies on early-onset psychosis, thus more studies are needed to be able to propose targeted therapies for a point when the disease has just started or has not yet progressed.
肠-脑-微生物群轴之间的关系在精神疾病研究中已变得极为重要，因为它可能代表了精神疾病治疗的新靶点。迄今为止，现有文献表明微生物群可能影响包括精神病在内的多种疾病的病理生理学。本综述的目的是总结评估微生物群差异以及与精神病相关的代谢后果的临床和临床前研究。目前的数据表明，精神分裂症（SZ）患者中[具体菌属]增加，同时谷氨酸-谷氨酰胺-γ-氨基丁酸循环、血清色氨酸、犬尿烯酸（KYNA）和短链脂肪酸（SCFAs）水平也发生改变。关于早发性精神病的研究仍然很少，因此需要更多研究，以便能够在疾病刚刚开始或尚未进展时提出针对性疗法。
