Salomão Rebecca, Assis Victoria, de Sousa Neto Ivo Vieira, Petriz Bernardo, Babault Nicolas, Durigan João Luiz Quaglioti, de Cássia Marqueti Rita
Laboratory of Molecular Analysis, Postgraduate Program in Health and Sciences and Technology, Faculty of Ceilândia, University of Brasilia, Brasilia 72220-275, DF, Brazil.
Laboratory of Molecular Analysis, Postgraduate Program in Rehabilitation Sciences, Faculty of Ceilândia, University of Brasilia, Brasilia 72220-275, DF, Brazil.
Biology (Basel). 2023 Jun 10;12(6):843. doi: 10.3390/biology12060843.
MMPs are enzymes involved in SARS-CoV-2 pathogenesis. Notably, the proteolytic activation of MMPs can occur through angiotensin II, immune cells, cytokines, and pro-oxidant agents. However, comprehensive information regarding the impact of MMPs in the different physiological systems with disease progression is not fully understood. In the current study, we review the recent biological advances in understanding the function of MMPs and examine time-course changes in MMPs during COVID-19. In addition, we explore the interplay between pre-existing comorbidities, disease severity, and MMPs. The reviewed studies showed increases in different MMP classes in the cerebrospinal fluid, lung, myocardium, peripheral blood cells, serum, and plasma in patients with COVID-19 compared to non-infected individuals. Individuals with arthritis, obesity, diabetes, hypertension, autoimmune diseases, and cancer had higher MMP levels when infected. Furthermore, this up-regulation may be associated with disease severity and the hospitalization period. Clarifying the molecular pathways and specific mechanisms that mediate MMP activity is important in developing optimized interventions to improve health and clinical outcomes during COVID-19. Furthermore, better knowledge of MMPs will likely provide possible pharmacological and non-pharmacological interventions. This relevant topic might add new concepts and implications for public health in the near future.
基质金属蛋白酶（MMPs）是参与严重急性呼吸综合征冠状病毒2（SARS-CoV-2）发病机制的酶。值得注意的是，MMPs的蛋白水解激活可通过血管紧张素II、免疫细胞、细胞因子和促氧化剂发生。然而，关于MMPs在不同生理系统中随疾病进展所产生影响的全面信息尚未完全明确。在本研究中，我们回顾了在理解MMPs功能方面的最新生物学进展，并研究了新型冠状病毒肺炎（COVID-19）期间MMPs的时间进程变化。此外，我们还探讨了既往合并症、疾病严重程度与MMPs之间的相互作用。经审查的研究表明，与未感染个体相比，COVID-19患者的脑脊液、肺、心肌、外周血细胞、血清和血浆中不同类别的MMPs有所增加。患有关节炎、肥胖症、糖尿病、高血压、自身免疫性疾病和癌症的个体在感染时MMP水平更高。此外，这种上调可能与疾病严重程度和住院时间有关。阐明介导MMP活性的分子途径和具体机制对于制定优化干预措施以改善COVID-19期间的健康状况和临床结局至关重要。此外，对MMPs的深入了解可能会提供可能的药物和非药物干预措施。这一相关主题可能会在不久的将来为公共卫生增添新的概念和启示。
