Sacher M, Unger F D, Eder G
Padiatr Padol. 1986;21(2):141-6.
5 infants (3 boys and 2 girls) were infected vertically with hepatitis B virus by their healthy anti-HBe positive HBsAg carrier mothers. First sign of infection in the infants occurred 1 to 6 months after birth. The course of the disease was as follows: subclinical hepatitis B (1 case), acute hepatitis B with complete resolution (1 case), fatal fulminant hepatitis B (1 case), chronic persistent hepatitis B (1 case), and chronic active hepatitis with rapid progression to cirrhosis. We conclude that anti-HBe positive hepatitis B carrier mothers may be infective and thus may cause serious, eventually fatal disease in their infants. Passive-active immunization must be given to infants of all hepatitis B carrier mothers irrespective if they are anti-HBe positive or not.
5名婴儿（3名男孩和2名女孩）被其健康的抗-HBe阳性HBsAg携带者母亲垂直感染了乙型肝炎病毒。婴儿感染的首个迹象出现在出生后1至6个月。疾病过程如下：亚临床型乙型肝炎（1例）、急性乙型肝炎且完全康复（1例）、致命性暴发性乙型肝炎（1例）、慢性持续性乙型肝炎（1例）以及慢性活动性乙型肝炎并迅速进展为肝硬化。我们得出结论，抗-HBe阳性的乙型肝炎携带者母亲可能具有传染性，因此可能在其婴儿中引发严重的、最终致命的疾病。所有乙型肝炎携带者母亲的婴儿都必须接受被动-主动免疫，无论她们是否为抗-HBe阳性。
