Graduate Program on Pharmaceutical Sciences, Department of Biological & Health Sciences, Federal University of Amapa, Macapa 68903-419, Brazil.
Laboratory of Quality Control, Bromatology and Microbiology, Department of Biological & Health Sciences, Federal University of Amapa, Macapa 68903-419, Brazil.
Int J Mol Sci. 2023 Jun 7;24(12):9832. doi: 10.3390/ijms24129832.
Systemic arterial hypertension (SAH) is one of the most prevalent chronic diseases worldwide and, when dysregulated, may cause serious complications. Losartan (LOS) blocks relevant physiological aspects of hypertension, acting mainly on the reduction of peripheral vascular resistance. Complications of hypertension include nephropathy, in which diagnosis is based on the observation of functional or structural renal dysfunction. Therefore, blood pressure control is essential to attenuate the progression of chronic kidney disease (CKD). In this study, H NMR metabolomics were used to differentiate hypertensive and chronic renal patients. Plasmatic levels of LOS and EXP3174, obtained by liquid chromatography coupled with mass-mass spectroscopy, were correlated with blood pressure control, biochemical markers and the metabolomic fingerprint of the groups. Some biomarkers have been correlated with key aspects of hypertension and CKD progression. For instance, higher levels of trigonelline, urea and fumaric acid were found as characteristic markers of kidney failure. In the hypertensive group, the urea levels found could indicate the onset of kidney damage when associated with uncontrolled blood pressure. In this sense, the results point to a new approach to identify CKD in early stages and may contribute to improving pharmacotherapy and reducing morbidity and mortality associated with hypertension and CKD.
系统性动脉高血压（SAH）是全球最普遍的慢性疾病之一，当其失调时可能会导致严重的并发症。氯沙坦（LOS）可阻断高血压的相关生理方面，主要作用于降低外周血管阻力。高血压的并发症包括肾病，其诊断基于对肾功能的功能性或结构性障碍的观察。因此，控制血压对于减轻慢性肾病（CKD）的进展至关重要。在这项研究中，我们使用核磁共振代谢组学来区分高血压和慢性肾病患者。通过液相色谱-质谱联用技术获得的氯沙坦和 EXP3174 的血浆水平与血压控制、生化标志物以及各组的代谢组指纹图谱相关联。一些生物标志物与高血压和 CKD 进展的关键方面相关。例如，较高水平的瓜氨酸、尿素和延胡索酸被认为是肾功能衰竭的特征性标志物。在高血压组中，与未控制的血压相关联时，发现的尿素水平可能表明肾脏损伤的发生。从这个意义上说，研究结果为识别早期 CKD 提供了一种新方法，并可能有助于改善药物治疗，降低与高血压和 CKD 相关的发病率和死亡率。
