• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

探讨 COL1A1 的调控因子。

Reviewing the Regulators of COL1A1.

机构信息

Centre of Systems Biology, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.

Laboratory of Biology, University of Athens School of Medicine, 11527 Athens, Greece.

出版信息

Int J Mol Sci. 2023 Jun 11;24(12):10004. doi: 10.3390/ijms241210004.

DOI:10.3390/ijms241210004
PMID:37373151
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10298483/
Abstract

The collagen family contains 28 proteins, predominantly expressed in the extracellular matrix (ECM) and characterized by a triple-helix structure. Collagens undergo several maturation steps, including post-translational modifications (PTMs) and cross-linking. These proteins are associated with multiple diseases, the most pronounced of which are fibrosis and bone diseases. This review focuses on the most abundant ECM protein highly implicated in disease, type I collagen (collagen I), in particular on its predominant chain collagen type I alpha 1 (COLα1 (I)). An overview of the regulators of COLα1 (I) and COLα1 (I) interactors is presented. Manuscripts were retrieved searching PubMed, using specific keywords related to COLα1 (I). regulators at the epigenetic, transcriptional, post-transcriptional and post-translational levels include DNA Methyl Transferases (DNMTs), Tumour Growth Factor β (TGFβ), Terminal Nucleotidyltransferase 5A (TENT5A) and Bone Morphogenic Protein 1 (BMP1), respectively. COLα1 (I) interacts with a variety of cell receptors including integrinβ, Endo180 and Discoidin Domain Receptors (DDRs). Collectively, even though multiple factors have been identified in association to COLα1 (I) function, the implicated pathways frequently remain unclear, underscoring the need for a more spherical analysis considering all molecular levels simultaneously.

摘要

胶原家族包含 28 种蛋白质，主要表达于细胞外基质（ECM），其特征为三螺旋结构。胶原经历多种成熟步骤，包括翻译后修饰（PTMs）和交联。这些蛋白与多种疾病相关，其中最明显的是纤维化和骨疾病。本综述聚焦于在疾病中高度涉及的最丰富的 ECM 蛋白，即 I 型胶原（胶原 I），特别是其主要链 I 型胶原α1（COLα1（I））。本文概述了 COLα1（I）及其相互作用蛋白的调控因子。通过使用与 COLα1（I）相关的特定关键字在 PubMed 上检索文献。COLα1（I）在表观遗传、转录、转录后和翻译后水平的调控因子分别为 DNA 甲基转移酶（DNMTs）、肿瘤生长因子β（TGFβ）、末端核苷酸转移酶 5A（TENT5A）和骨形态发生蛋白 1（BMP1）。COLα1（I）与多种细胞受体相互作用，包括整合素β、Endo180 和盘状结构域受体（DDRs）。尽管已经确定了与 COLα1（I）功能相关的多种因素，但涉及的途径常常仍不清楚，这突显了需要同时考虑所有分子水平进行更全面的分析。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/845c/10298483/75ed3dde15e3/ijms-24-10004-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/845c/10298483/e46ee0fb9417/ijms-24-10004-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/845c/10298483/c2bdd79ae696/ijms-24-10004-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/845c/10298483/16f59c6374a2/ijms-24-10004-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/845c/10298483/a2c588bd9d3d/ijms-24-10004-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/845c/10298483/75ed3dde15e3/ijms-24-10004-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/845c/10298483/e46ee0fb9417/ijms-24-10004-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/845c/10298483/c2bdd79ae696/ijms-24-10004-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/845c/10298483/16f59c6374a2/ijms-24-10004-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/845c/10298483/a2c588bd9d3d/ijms-24-10004-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/845c/10298483/75ed3dde15e3/ijms-24-10004-g005.jpg

相似文献

1
Reviewing the Regulators of COL1A1.探讨 COL1A1 的调控因子。
Int J Mol Sci. 2023 Jun 11;24(12):10004. doi: 10.3390/ijms241210004.
2
Sensing extracellular matrix: an update on discoidin domain receptor function.感知细胞外基质：盘状结构域受体功能的最新进展
Cell Signal. 2006 Aug;18(8):1108-16. doi: 10.1016/j.cellsig.2006.02.012. Epub 2006 Feb 28.
3
Quantitative proteomic profiling of extracellular matrix and site-specific collagen post-translational modifications in an model of lung fibrosis.肺纤维化模型中细胞外基质的定量蛋白质组学分析及位点特异性胶原蛋白的翻译后修饰
Matrix Biol Plus. 2019 Apr 13;1:100005. doi: 10.1016/j.mbplus.2019.04.002. eCollection 2019 Feb.
4
Collagen recognition and transmembrane signalling by discoidin domain receptors.盘状结构域受体对胶原蛋白的识别与跨膜信号传导
Biochim Biophys Acta. 2013 Oct;1834(10):2187-94. doi: 10.1016/j.bbapap.2012.10.014. Epub 2012 Nov 2.
5
Discoidin domain receptors: Micro insights into macro assemblies.卷曲螺旋结构域受体：宏观组装的微观洞察。
Biochim Biophys Acta Mol Cell Res. 2019 Nov;1866(11):118496. doi: 10.1016/j.bbamcr.2019.06.010. Epub 2019 Jun 21.
6
Getting a grip on adhesion: Cadherin switching and collagen signaling.把握黏附：钙黏蛋白转换和胶原信号。
Biochim Biophys Acta Mol Cell Res. 2019 Nov;1866(11):118472. doi: 10.1016/j.bbamcr.2019.04.002. Epub 2019 Apr 5.
7
A novel functional role of collagen glycosylation: interaction with the endocytic collagen receptor uparap/ENDO180.胶原糖基化的新功能作用：与内吞胶原受体 uparap/ENDO180 的相互作用。
J Biol Chem. 2011 Sep 16;286(37):32736-48. doi: 10.1074/jbc.M111.266692. Epub 2011 Jul 18.
8
TGFβ1-Endo180-dependent collagen deposition is dysregulated at the tumour-stromal interface in bone metastasis.TGFβ1-Endo180 依赖性胶原蛋白沉积在骨转移中的肿瘤-基质界面失调。
J Pathol. 2012 Apr;226(5):775-83. doi: 10.1002/path.3958. Epub 2011 Dec 8.
9
The discoidin domain receptor DDR2 is a receptor for type X collagen.盘状结构域受体DDR2是X型胶原蛋白的受体。
Matrix Biol. 2006 Aug;25(6):355-64. doi: 10.1016/j.matbio.2006.05.006. Epub 2006 May 26.
10
Discoidin domain receptors promote α1β1- and α2β1-integrin mediated cell adhesion to collagen by enhancing integrin activation.Discoidin domain receptors 通过增强整合素的激活促进 α1β1-和 α2β1-整合素介导的细胞对胶原蛋白的黏附。
PLoS One. 2012;7(12):e52209. doi: 10.1371/journal.pone.0052209. Epub 2012 Dec 20.

引用本文的文献

1
Current Mechanobiological Pathways and Therapies Driving Spinal Health.驱动脊柱健康的当前机械生物学途径与疗法
Bioengineering (Basel). 2025 Aug 20;12(8):886. doi: 10.3390/bioengineering12080886.
2
Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model.高三尖杉酯碱减轻体外皮肤衰老模型中的细胞外基质降解、皮肤屏障功能障碍和炎症。
Curr Issues Mol Biol. 2025 Aug 10;47(8):642. doi: 10.3390/cimb47080642.
3
COL1A1 drives tumor progression in kidney renal clear cell carcinoma by regulating EMT through the PI3K/Akt pathway.

本文引用的文献

1
PubChem 2023 update.PubChem 2023 更新。
Nucleic Acids Res. 2023 Jan 6;51(D1):D1373-D1380. doi: 10.1093/nar/gkac956.
2
Transforming growth factor-β in tumour development.肿瘤发生发展过程中的转化生长因子-β
Front Mol Biosci. 2022 Oct 4;9:991612. doi: 10.3389/fmolb.2022.991612. eCollection 2022.
3
Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome.胶原降解依赖性 DDR1 信号决定胰腺癌的结局。
COL1A1通过PI3K/Akt途径调节上皮-间质转化，从而驱动肾透明细胞癌的肿瘤进展。
Cancer Cell Int. 2025 Aug 25;25(1):314. doi: 10.1186/s12935-025-03956-y.
4
Shikonin as a therapeutic agent in renal cell carcinoma: insights from TEK-related causal association with glaucoma.紫草素作为肾细胞癌的治疗药物：来自与青光眼相关的TEK因果关联的见解。
Front Pharmacol. 2025 Jul 30;16:1580704. doi: 10.3389/fphar.2025.1580704. eCollection 2025.
5
A Naturally Occurring Urinary Collagen Type I Alpha 1-Derived Peptide Inhibits Collagen Type I-Induced Endothelial Cell Migration at Physiological Concentrations.一种天然存在的尿源性I型胶原α1衍生肽在生理浓度下可抑制I型胶原诱导的内皮细胞迁移。
Int J Mol Sci. 2025 Aug 2;26(15):7480. doi: 10.3390/ijms26157480.
6
Targeting collagen to optimize cancer immunotherapy.靶向胶原蛋白以优化癌症免疫疗法。
Exp Hematol Oncol. 2025 Jul 29;14(1):101. doi: 10.1186/s40164-025-00691-y.
7
Enhanced THBS2 promotes collagen synthesis and inflammatory secretome of fibroblasts in idiopathic pulmonary fibrosis.增强的THBS2促进特发性肺纤维化中成纤维细胞的胶原蛋白合成和炎性分泌组。
Sci Rep. 2025 Jul 17;15(1):25926. doi: 10.1038/s41598-025-09318-y.
8
Exploring Schiff Bases Derived from 2-hydroxybenzaldehyde as Potential Anticancer Agents: Synthesis, Characterization, Molecular Docking and in-vitro Evaluation.探索源自2-羟基苯甲醛的席夫碱作为潜在抗癌剂：合成、表征、分子对接及体外评价
Cell Biochem Biophys. 2025 Jul 16. doi: 10.1007/s12013-025-01826-y.
9
The type I collagen paradox in PDAC progression: microenvironmental protector turned tumor accomplice.胰腺癌进展中的I型胶原蛋白悖论：微环境保护者变成肿瘤帮凶。
J Transl Med. 2025 Jul 4;23(1):744. doi: 10.1186/s12967-025-06778-8.
10
Comprehensive Computational Assessment of SNAI1 and SNAI2 in Gastric Cancer: Linking EMT, Tumor Microenvironment, and Survival Outcomes.胃癌中SNAI1和SNAI2的综合计算评估：连接上皮-间质转化、肿瘤微环境和生存结果
Cancer Inform. 2025 Jun 30;24:11769351251352892. doi: 10.1177/11769351251352892. eCollection 2025.
Nature. 2022 Oct;610(7931):366-372. doi: 10.1038/s41586-022-05169-z. Epub 2022 Oct 5.
4
TFLink: an integrated gateway to access transcription factor-target gene interactions for multiple species.TFLink：一个集成的网关，用于访问多个物种的转录因子-靶基因相互作用。
Database (Oxford). 2022 Sep 16;2022. doi: 10.1093/database/baac083.
5
Cell-Type-Specific Effects of the Ovarian Cancer G-Protein Coupled Receptor (OGR1) on Inflammation and Fibrosis; Potential Implications for Idiopathic Pulmonary Fibrosis.卵巢癌 G 蛋白偶联受体（OGR1）对炎症和纤维化的细胞类型特异性作用；对特发性肺纤维化的潜在影响。
Cells. 2022 Aug 16;11(16):2540. doi: 10.3390/cells11162540.
6
LncRNA LINC00511 promotes COL1A1-mediated proliferation and metastasis by sponging miR-126-5p/miR-218-5p in lung adenocarcinoma.长链非编码 RNA LINC00511 通过海绵吸附 miR-126-5p/miR-218-5p 促进肺腺癌 COL1A1 介导的增殖和转移。
BMC Pulm Med. 2022 Jul 16;22(1):272. doi: 10.1186/s12890-022-02070-3.
7
Identification of COL1A1 associated with immune infiltration in brain lower grade glioma.鉴定 COL1A1 与脑低级别胶质瘤免疫浸润的关联。
PLoS One. 2022 Jul 5;17(7):e0269533. doi: 10.1371/journal.pone.0269533. eCollection 2022.
8
Remodeling the tumor microenvironment via blockade of LAIR-1 and TGF-β signaling enables PD-L1-mediated tumor eradication.通过阻断 LAIR-1 和 TGF-β 信号重塑肿瘤微环境可实现 PD-L1 介导的肿瘤清除。
J Clin Invest. 2022 Apr 15;132(8). doi: 10.1172/JCI155148.
9
Collagen 1a1 Expression by Airway Macrophages Increases In Fibrotic ILDs and Is Associated With FVC Decline and Increased Mortality.气道巨噬细胞中胶原 1a1 的表达增加与纤维化 ILD 有关，并与 FVC 下降和死亡率增加相关。
Front Immunol. 2021 Nov 17;12:645548. doi: 10.3389/fimmu.2021.645548. eCollection 2021.
10
TcoFBase: a comprehensive database for decoding the regulatory transcription co-factors in human and mouse.TcoFBase：一个用于解码人类和小鼠中调控转录共因子的综合数据库。
Nucleic Acids Res. 2022 Jan 7;50(D1):D391-D401. doi: 10.1093/nar/gkab950.