Wallenberg Centre for Molecular Medicine, Lund University, 22100 Lund, Sweden.
Department of Clinical Sciences, Lund University, 20502 Malmö, Sweden.
Int J Mol Sci. 2023 Jun 13;24(12):10064. doi: 10.3390/ijms241210064.
Epidemiological studies have associated plasma galectin-4 (Gal-4) levels with prevalent and incident diabetes, and with an increased risk of coronary artery disease. To date, data regarding possible associations between plasma Gal-4 and stroke are lacking. Using linear and logistic regression analyses, we tested Gal-4 association with prevalent stroke in a population-based cohort. Additionally, in mice fed a high-fat diet (HFD), we investigated whether plasma Gal-4 increases in response to ischemic stroke. Plasma Gal-4 was higher in subjects with prevalent ischemic stroke, and was associated with prevalent ischemic stroke (odds ratio 1.52; 95% confidence interval 1.01-2.30; = 0.048) adjusted for age, sex, and covariates of cardiometabolic health. Plasma Gal-4 increased after experimental stroke in both controls and HFD-fed mice. HFD exposure was devoid of impact on Gal-4 levels. This study demonstrates higher plasma Gal-4 levels in both experimental stroke and in humans that experienced ischemic stroke.
流行病学研究将血浆半乳糖凝集素-4（Gal-4）水平与现患和新发糖尿病以及冠心病风险增加相关联。迄今为止，关于血浆 Gal-4 与中风之间可能存在关联的数据尚缺乏。我们使用线性和逻辑回归分析，在基于人群的队列中测试了 Gal-4 与现患中风的关联。此外，在高脂饮食（HFD）喂养的小鼠中，我们研究了血浆 Gal-4 是否会因缺血性中风而增加。与现患缺血性中风的受试者相比，血浆 Gal-4 水平较高，且与现患缺血性中风相关（比值比 1.52；95%置信区间 1.01-2.30；=0.048），校正了年龄、性别和心血管代谢健康的协变量。在对照和 HFD 喂养的小鼠中，实验性中风后血浆 Gal-4 水平均升高。HFD 暴露对 Gal-4 水平没有影响。本研究表明，实验性中风和经历缺血性中风的人类的血浆 Gal-4 水平均较高。
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