Department of Neurology, Taizhou Hospital, Wenzhou Medical University, Linhai, 317000, China.
Medical Research Center, Taizhou Hospital, Wenzhou Medical University, Linhai, 317000, China.
Sci Rep. 2017 Jan 23;7:40994. doi: 10.1038/srep40994.
The aim of this study was to assess the expression patterns of serum galectin-1 (Gal-1), galectin-3 (Gal-3), galectin-9 (Gal-9), and galectin-3 binding protein (Gal-3BP) and their associations with stroke outcome in large artery atherosclerotic (LAA) stroke. The serum levels of Gal-1, Gal-3, Gal-9, and Gal-3BP were measured by ELISA in 130 patients with LAA stroke and 130 age- and sex-matched controls. Serum samples were collected from the patients on day 1, day 6, and in the 4th week after ischaemic stroke (IS). An unfavourable outcome was defined as a modified Rankin Scale score of >2 on day 90 after IS. Our results indicated that the Gal-3 and Gal-9 levels were higher in patients with LAA stroke than in controls. A higher Gal-3 level was independently associated with an unfavourable outcome both on day 1 and day 6 after IS. In addition, Gal-9 and Gal-1 levels were upregulated on day 6 and in the 4th week after IS, respectively. For Gal-3BP, no difference was detected between patients and controls and no predictive value was found in patients. In conclusion, these findings suggest that the serum levels of Gal-1, Gal-3, and Gal-9 may be associated with LAA stroke.
本研究旨在评估血清半乳糖凝集素-1（Gal-1）、半乳糖凝集素-3（Gal-3）、半乳糖凝集素-9（Gal-9）和半乳糖凝集素-3 结合蛋白（Gal-3BP）的表达模式及其与大动脉粥样硬化性（LAA）卒中患者预后的关系。采用 ELISA 法检测 130 例 LAA 卒中患者和 130 例年龄和性别匹配的对照组患者的血清 Gal-1、Gal-3、Gal-9 和 Gal-3BP 水平。患者入院第 1 天、第 6 天和缺血性卒中（IS）后第 4 周采集血清样本。改良 Rankin 量表评分>2 定义为不良预后。结果表明，LAA 卒中患者的 Gal-3 和 Gal-9 水平高于对照组。Gal-3 水平升高与 IS 后第 1 天和第 6 天不良预后独立相关。此外，Gal-9 和 Gal-1 水平分别于 IS 后第 6 天和第 4 周上调。Gal-3BP 水平在患者与对照组之间无差异，在患者中也无预测价值。综上，这些发现提示血清 Gal-1、Gal-3 和 Gal-9 水平可能与 LAA 卒中相关。
