Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing 100875, China.
Int J Mol Sci. 2023 Jun 17;24(12):10265. doi: 10.3390/ijms241210265.
As one of the most important components of the innate immune system, neutrophils are always at the forefront of the response to diseases. The immune functions of neutrophils include phagocytosis, degranulation, production of reactive oxygen species, and the production of neutrophil extracellular traps (NETs). NETs are composed of deconcentrated chromatin DNA, histones, myeloperoxidase (MPO) and neutrophil elastase (NE), playing an important role in the resistance to some pathogenic microbial invasions. Until recent years, when NETs were found to play a critical role in cancer. NETs play bidirectional regulation both positive and negative roles in the development and progression of cancer. Targeted NETs may provide new therapeutic strategies for the treatment of cancer. However, the molecular and cellular regulatory mechanisms underlying the formation and role of NET in cancer remain unclear. This review just summarizes the recent progress in regulatory mechanisms about the formation of NETs and their role in cancers.
作为先天免疫系统的最重要组成部分之一，中性粒细胞始终处于疾病反应的最前沿。中性粒细胞的免疫功能包括吞噬作用、脱颗粒作用、产生活性氧物质和产生中性粒细胞胞外陷阱（NETs）。NETs 由浓缩染色质 DNA、组蛋白、髓过氧化物酶（MPO）和中性粒细胞弹性蛋白酶（NE）组成，在抵抗某些致病微生物入侵方面发挥着重要作用。直到最近几年，当 NETs 被发现对癌症具有关键作用时。NETs 在癌症的发展和进展中发挥着双向调节作用，既有积极作用也有消极作用。靶向 NETs 可能为癌症的治疗提供新的治疗策略。然而，NET 在癌症中形成和作用的分子和细胞调节机制尚不清楚。本文综述了 NET 形成的调节机制及其在癌症中的作用的最新进展。
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