School of Pharmacy, Second Military Medical University, Shanghai, China.
Front Immunol. 2022 Sep 14;13:977493. doi: 10.3389/fimmu.2022.977493. eCollection 2022.
Fungal infections are a growing health care challenge. Neutrophils play a key role in defense against fungal infections. There are many effective ways for neutrophils to eliminate fungal invaders, such as phagocytosis, oxidative bursts, and the formation of extracellular traps. This process has received considerable attention and has made rapid progress since neutrophil extracellular traps (NETs) formation was described. Here, we describe the formation, induction, and function of NETs, as well as fungal strategies against NETs hunting. We highlight the effects of NETs on common fungal pathogens and how these pathogens survive.
真菌感染是一个日益严峻的健康挑战。中性粒细胞在抵御真菌感染方面发挥着关键作用。中性粒细胞有许多有效的方法来消灭真菌入侵者，如吞噬作用、氧化爆发和细胞外陷阱的形成。自从描述了中性粒细胞细胞外陷阱（NETs）的形成以来，这个过程引起了相当大的关注，并取得了快速的进展。在这里，我们描述了 NETs 的形成、诱导和功能，以及真菌对抗 NETs 捕猎的策略。我们强调了 NETs 对常见真菌病原体的影响，以及这些病原体是如何存活的。
