Department of Pharmacotherapy, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 739-0046, Japan.
Department of Dermatology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 739-0046, Japan.
Int J Mol Sci. 2023 Jun 19;24(12):10320. doi: 10.3390/ijms241210320.
Chronic spontaneous urticaria (CSU) is a common skin disorder characterized by daily or almost daily recurring skin edema and flare with itch and pruritus anywhere on the body for more than 6 weeks. Although basophil- and mast cell-released inflammatory mediators, such as histamine, play important roles in the pathogenesis of CSU, the detailed underlying mechanism is not clear. Since several auto-antibodies, IgGs which recognize IgE or the high-affinity IgE receptor (FcεRI) and IgEs against other self-antigens, are detected in CSU patients, they are considered to activate both mast cells in the skin and basophils circulating in the blood. In addition, we and other groups demonstrated that the coagulation and complement system also contribute to the development of urticaria. Here, we summarized the behaviors, markers and targets of basophils in relation to the coagulation-complement system, and for the treatment of CSU.
慢性自发性荨麻疹（CSU）是一种常见的皮肤疾病，其特征为全身性皮肤水肿和红肿反复发作，每天或几乎每天都会发生，且瘙痒和刺痛感持续超过 6 周。尽管嗜碱性粒细胞和肥大细胞释放的炎症介质，如组胺，在 CSU 的发病机制中起着重要作用，但详细的潜在机制尚不清楚。由于在 CSU 患者中检测到几种自身抗体，即识别 IgE 或高亲和力 IgE 受体（FcεRI）的 IgG 和针对其他自身抗原的 IgE，它们被认为可以激活皮肤中的肥大细胞和循环血液中的嗜碱性粒细胞。此外，我们和其他研究小组还证明了凝血和补体系统也有助于荨麻疹的发展。在这里，我们总结了嗜碱性粒细胞与凝血-补体系统相关的行为、标志物和靶点，以及 CSU 的治疗方法。
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