Department of Obstetrics and Gynecology, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Department of Radiology, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Prenat Diagn. 2022 Jan;42(1):141-150. doi: 10.1002/pd.6045. Epub 2021 Sep 28.
To determine whether the presence of brain sparing in fetal growth restricted (FGR) fetuses involves elevation of the cerebral injury biomarker S100B in maternal circulation.
We included 63 women with suspected small for gestational age (SGA) fetuses between 24 and 35 +6/7 weeks of gestation. Maternal plasma angiogenic factors measurements and sonographic evaluation were performed at recruitment. Next, we subdivided our SGA cohort into three groups: SGA fetuses, FGR fetuses without brain-sparing, and FGR fetuses with brain-sparing (FGR-BS). Serum S100B concentration was calculated as S100B µg/L, S100B MoM, and the ratio S100B/ estimated fetal weight (EFW). We also report one case of S100B concentration surge in maternal serum following the diagnosis of fetal intraventricular hemorrhage (IVH).
The FGR-BS group had higher maternal S100B µg/L (p < 0.01, p < 0.05, respectively), S100B MoM (p < 0.001, p < 0.001, respectively), and S100B/EFW (p < 0.001, p < 0.01, respectively), compared to the SGA and FGR groups. In the case report, maternal serum S100B concentrations were 0.0346 µg/L before, and 0.0874 µg/L after IVH occurrence.
S100B concentration in maternal serum increased in pregnancies complicated by FGR and brain sparing. These results may substantiate in-utero cerebral injury and may explain the adverse neurocognitive outcomes reported for this group.
确定胎儿生长受限（FGR）胎儿中是否存在脑保护现象是否与母体循环中脑损伤生物标志物 S100B 升高有关。
我们纳入了 63 名妊娠 24 至 35+6/7 周的疑似胎儿生长受限（SGA）孕妇。在招募时进行了母体血浆血管生成因子测量和超声评估。接下来，我们将 SGA 队列分为三组：SGA 胎儿、无脑保护的 FGR 胎儿和有脑保护的 FGR 胎儿（FGR-BS）。血清 S100B 浓度以 S100B µg/L、S100B MoM 和 S100B/估计胎儿体重（EFW）的比值计算。我们还报告了一例胎儿脑室内出血（IVH）诊断后母体血清 S100B 浓度激增的病例。
与 SGA 组和 FGR 组相比，FGR-BS 组的母体 S100B µg/L（p<0.01，p<0.05）、S100B MoM（p<0.001，p<0.001）和 S100B/EFW（p<0.001，p<0.01）均升高。在病例报告中，母亲血清 S100B 浓度在 IVH 发生前为 0.0346 µg/L，发生后为 0.0874 µg/L。
伴有脑保护的 FGR 孕妇母体血清 S100B 浓度升高。这些结果可能证实了宫内脑损伤，并可能解释了该组报道的不良神经认知结局。
