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血脂异常的老年人中潜在不适当用药情况

Potentially Inappropriate Medications Use among Older Adults with Dyslipidaemia.

作者信息

Alwhaibi Monira, Alkofide Hadeel

机构信息

Medication Safety Research Chair, College of Pharmacy, King Saud University, Riyadh 11149, Saudi Arabia.

Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh 11149, Saudi Arabia.

出版信息

J Clin Med. 2023 Jun 15;12(12):4063. doi: 10.3390/jcm12124063.

Abstract

BACKGROUND

Since older patients with dyslipidemia frequently receive many prescriptions, medication errors are typical and expected in this population. This risk has increased by using potentially inappropriate medications. The 2019 Beers criteria were used in this study to investigate potentially inappropriate medication use among older individuals with dyslipidemia.

METHODS

A cross-sectional retrospective analysis used data from electronic medical records from an ambulatory-care environment. Patients with dyslipidemia who were older adults (>65 years old) were included. To describe and find potential determinants of potentially inappropriate medication usage, descriptive statistics and logistic regression were employed.

RESULTS

This study included 2209 older adults (age ≥ 65) with dyslipidemia. The mean age was 72.1 ± 6.0 years, and the majority of the study sample had hypertension (83.7%) and diabetes (61.7%), and around 80.0% were using polypharmacy. The prevalence of potentially inappropriate medications to be avoided among older adults with dyslipidemia was 48.6%. A high risk of potentially inappropriate medication usage was found in older patients with dyslipidemia who had polypharmacy and comorbid diabetes, ischemic heart disease, and anxiety.

CONCLUSIONS

This study showed that the number of medications prescribed and the presence of concurrent chronic health conditions are important indicators of the risk of potentially inappropriate medications in ambulatory older patients with dyslipidemia.

摘要

背景

由于老年血脂异常患者经常接受多种药物治疗,用药错误在该人群中很常见且难以避免。使用潜在不适当药物会增加这种风险。本研究采用2019年版《美国老年病学会黑名单》来调查老年血脂异常患者中潜在不适当用药情况。

方法

采用横断面回顾性分析,使用来自门诊医疗环境电子病历的数据。纳入年龄大于65岁的血脂异常患者。采用描述性统计和逻辑回归来描述和寻找潜在不适当用药的潜在决定因素。

结果

本研究纳入了2209名年龄≥65岁的血脂异常老年人。平均年龄为72.1±6.0岁,大多数研究样本患有高血压(83.7%)和糖尿病(61.7%),约80.0%的患者使用多种药物。血脂异常老年人中应避免使用的潜在不适当药物的患病率为48.6%。在患有多种疾病且合并糖尿病、缺血性心脏病和焦虑症的老年血脂异常患者中,发现潜在不适当用药的风险较高。

结论

本研究表明,用药数量以及同时存在的慢性健康状况是门诊老年血脂异常患者潜在不适当用药风险的重要指标。

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