Faculty of Pharmacy, Medical University of Sofia, Sofia, Bulgaria.
Front Public Health. 2022 Mar 3;10:743138. doi: 10.3389/fpubh.2022.743138. eCollection 2022.
Polypharmacy and inappropriate prescribing are overlooked issues in Bulgaria. We aimed at collecting and analyzing global literature on the most prevalent risk factors and investigating what they could reveal about current practice.
A systematic narrative review and meta-analysis was conducted on the topic, investigating the prevalence of polypharmacy, odds of potentially inappropriate medications (PIMs) due to polypharmacy, and the likelihood of developing a drug-related problem (DRP) due to PIMs. The results were then related to current demographic statistics to estimate the potential impact on Bulgarian elderly patients.
The prevalence of polypharmacy was estimated at 41% in elderly populations. The odds of a potentially inappropriate medication being prescribed were 2.095, with an expected 30.84% of those leading to a DRP. These numbers indicated that the expected Bulgarian elderly with polypharmacy should be 709,676 with 212,903 cases of DRPs.
Global polypharmacy rates seem to be on the rise, with an expected increase in DRPs.
药物滥用和不适当处方是保加利亚被忽视的问题。我们旨在收集和分析全球关于最常见风险因素的文献，并研究这些因素能反映出当前的实践情况。
对该主题进行了系统的叙述性综述和荟萃分析，调查了药物滥用的普遍性、因药物滥用而导致的潜在不适当药物的可能性以及因潜在不适当药物而导致药物相关问题的可能性。然后，将结果与当前的人口统计学统计数据相关联，以估计对保加利亚老年患者的潜在影响。
老年人中药物滥用的患病率估计为 41%。开出潜在不适当药物的可能性为 2.095，预计其中 30.84%会导致药物相关问题。这些数字表明，预期有 709676 名保加利亚老年患者存在药物滥用，其中 212903 例会出现药物相关问题。
全球药物滥用率似乎呈上升趋势，预计药物相关问题也会增加。
