Modulation of the centrally-evoked visceral alerting/defence response by changes in CSF pH at the ventral surface of the medulla oblongata and by systemic hypercapnia.

In the present study on nine cats, repeated tests were made of the effects of superfusion of the ventral surface of the medulla oblongata with acid or alkaline CSF. Only two animals showed slight hyperventilation, tachycardia, mesenteric vasoconstriction and variable changes in hindlimb vascular conductance when the ventral surface was superfused with acid CSF; alkaline CSF produced opposite effects. These changes are qualitatively similar to, but much smaller than, published results which support the idea that the central chemoreceptor areas for CO2 are near the surface of the ventral medulla. But, in accord with those who have disputed this idea, the remaining 7 animals showed no response to superfusion with acid or alkaline CSF. Yet, all 9 animals showed marked hyperventilation in response to inhalation of 5% or 8% CO2. These findings accord with the view that chemosensitive structures on the ventral medulla represent part, but not all of the central chemosensitive mechanism for CO2. Inhalation of CO2 also induced bradycardia, mesenteric vasodilatation and either vasodilatation or vasoconstriction in hindlimb, attributable to a predominance of the direct myocardial depressant and local vasodilator effects of CO2, over the increase in sympathetic activity produced by central hypercapnia. But, despite the different effects of acid CSF and inhaled CO2 on baselines, they produced comparable effects on the visceral altering/defence response evoked by electrical stimulation in the ventral amygdalo-hypothalamic pathway viz, the magnitude of the characteristic hindlimb dilatation was reduced while that of the mesenteric constriction was increased.(ABSTRACT TRUNCATED AT 250 WORDS)