Karagozoglu K Hakki, Mahraoui Anissa, Bot Joseph C J, Cha Seunghee, Ho Jean-Pierre T F, Helder Marco N, Brand Henk S, Bartelink Imke H, Vissink Arjan, Weisman Gary A, Jager Derk Hendrik Jan
Department of Oral and Maxillofacial Surgery/Oral Pathology, Amsterdam UMC, Location Vrije Universiteit Amsterdam, De Boelelaan 1118, 1081 HV Amsterdam, Noord-Holland, The Netherlands.
Department of Radiology and Nuclear Medicine, Amsterdam UMC, Location Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, Noord-Holland, The Netherlands.
J Clin Med. 2023 Jun 20;12(12):4152. doi: 10.3390/jcm12124152.
In sialendoscopy, ducts are dilated and the salivary glands are irrigated with saline. Contrast-enhanced ultrasound sialendoscopy (CEUSS), using microbubbles, may facilitate the monitoring of irrigation solution penetration in the ductal system and parenchyma. It is imperative to test CEUSS for its safety and feasibility in Sjögren's syndrome (SS) patients. CEUSS was performed on 10 SS patients. The primary outcomes were safety, determined by the occurrence of (serious) adverse events ((S)AEs), and feasibility. The secondary outcomes were unstimulated and stimulated whole saliva (UWS and SWS) flow rates, xerostomia inventory (XI), clinical oral dryness score, pain, EULAR Sjögren's syndrome patient reported index (ESSPRI), and gland topographical alterations. CEUSS was technically feasible in all patients. Neither SAEs nor systemic reactions related to the procedure were observed. The main AEs were postoperative pain (two patients) and swelling (two patients). Eight weeks after CEUSS, the median UWS and SWS flow had increased significantly from 0.10 to 0.22 mL/min ( = 0.028) and 0.41 to 0.61 mL/min ( = 0.047), respectively. Sixteen weeks after CEUSS, the mean XI was reduced from 45.2 to 34.2 ( = 0.02). We conclude that CEUSS is a safe and feasible treatment for SS patients. It has the potential to increase salivary secretion and reduce xerostomia, but this needs further investigation.
在唾液腺内镜检查中，导管会被扩张，并用生理盐水冲洗唾液腺。使用微泡的超声造影唾液腺内镜检查（CEUSS）可能有助于监测冲洗液在导管系统和实质中的渗透情况。必须对CEUSS在干燥综合征（SS）患者中的安全性和可行性进行测试。对10例SS患者进行了CEUSS检查。主要结局指标为安全性（由（严重）不良事件（（S）AE）的发生情况确定）和可行性。次要结局指标为非刺激性和刺激性全唾液（UWS和SWS）流速、口干量表（XI）、临床口腔干燥评分、疼痛、欧洲抗风湿病联盟干燥综合征患者报告指数（ESSPRI）以及腺体形态改变。CEUSS在所有患者中技术上均可行。未观察到与该操作相关的严重不良事件或全身反应。主要不良事件为术后疼痛（2例患者）和肿胀（2例患者）。CEUSS检查8周后，UWS和SWS流速的中位数分别从0.10显著增加至0.22 mL/分钟（ = 0.028）和从0.41增加至0.61 mL/分钟（ = 0.047）。CEUSS检查16周后，XI的平均值从45.2降至34.2（ = 0.02）。我们得出结论，CEUSS对SS患者是一种安全可行的治疗方法。它有可能增加唾液分泌并减轻口干，但这需要进一步研究。
