Maarse Floor, Huisinga Jitse F, Jager Derk Hendrik Jan, Brand Henk S
Department of Oral and Maxillofacial Surgery/Oral Pathology, Amsterdam UMC, Location Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.
JFH Dentists, 1901 GG Castricum, The Netherlands.
J Clin Med. 2024 Oct 3;13(19):5918. doi: 10.3390/jcm13195918.
: Sjögren's disease (SjD) is an autoimmune disease causing irreversible damage to the exocrine glands but can have symptoms throughout the entire body. The aim of this study is to determine the prevalence of Sjogren's disease (SjD) in the Netherlands, compare this with the prevalence for other countries in a systematic literature review. : In the first part of this study, the prevalence of SjD was determined at two academic dental clinics in the Netherlands by electronically analysing patient records. In the second part of this study, a systematic literature search was performed in PubMed. Studies in the English language reporting prevalence ratios (PRs), incidence ratios (IRs) or sufficient data to calculate these parameters were included. Population-based studies and population surveys aiming to examine an entire geographic region or using a clearly defined sampling procedure were included. Review studies were excluded. Studies that did not report sufficient data or contained no original data were excluded. Included studies were assessed using the Newcastle-Ottawa assessment scale. : At the dental clinic in Amsterdam, 76 SJD patients were identified among a patient population of 81941, resulting in a prevalence ratio of 93 per 100,000 (0.093%) patients. In Nijmegen, 21 SjD patients were identified in a total patient population of 14,240, resulting in a prevalence ratio of 147 per 100,000 (0.15%). Thirty-one studies were included in the systematic review. They varied in diagnostic criteria for SjD with the American-European Consensus Group (AECG) criteria being the most widely used. The reported prevalence ratio varied from 0.008% to 3.3%. The overall pooled prevalence ratio of SjD using the AECG criteria was 0.031%, while the pooled prevalence of SjD using the EU criteria was 0.029%. The overall pooled incidence ratio was 5.2 (95%CI 4.7 to 5.6) per 100,000 person-years. : The estimated prevalence ratio of SjD in the Netherlands (0.09% to 0.15%) falls within the worldwide range but is higher than the worldwide pooled prevalence ratio.
干燥综合征（SjD）是一种自身免疫性疾病，会对人体外分泌腺造成不可逆损害，且可累及全身。本研究旨在确定荷兰干燥综合征（SjD）的患病率，并通过系统文献综述将其与其他国家的患病率进行比较。
在本研究的第一部分，通过电子分析荷兰两家学术牙科诊所的患者记录，确定了SjD的患病率。在本研究的第二部分，在PubMed上进行了系统的文献检索。纳入了以英文发表的报告患病率比（PRs）、发病率比（IRs）或有足够数据计算这些参数的研究。纳入了旨在调查整个地理区域或采用明确定义抽样程序的基于人群的研究和人口调查。排除综述性研究。排除未报告足够数据或无原始数据的研究。使用纽卡斯尔-渥太华评估量表对纳入的研究进行评估。
在阿姆斯特丹的牙科诊所，在81941名患者中确定了76名SjD患者，患病率为每10万人中93例（0.093%）。在奈梅亨，在总共14240名患者中确定了21名SjD患者，患病率为每10万人中147例（0.15%）。系统综述纳入了31项研究。这些研究对SjD的诊断标准各不相同，其中美国-欧洲共识小组（AECG）标准使用最为广泛。报告的患病率比从0.008%到3.3%不等。使用AECG标准的SjD总体合并患病率为0.031%，而使用欧盟标准的SjD合并患病率为0.029%。总体合并发病率为每10万人年5.2（95%CI 4.7至5.6）。
荷兰SjD的估计患病率（0.09%至0.15%）在全球范围内，但高于全球合并患病率。
