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用于妊娠和分娩风险管理的机器学习方法

Machine Learning Methods for Pregnancy and Childbirth Risk Management.

作者信息

Kopanitsa Georgy, Metsker Oleg, Kovalchuk Sergey

机构信息

Faculty of Digital Transformations, ITMO University, 4 Birzhevaya Liniya, 199034 Saint-Petersburg, Russia.

Almazov National Medical Research Centre, Ulitsa Akkuratova, 2, 197341 Saint-Petersburg, Russia.

出版信息

J Pers Med. 2023 Jun 10;13(6):975. doi: 10.3390/jpm13060975.

Abstract

Machine learning methods enable medical systems to automatically generate data-driven decision support models using real-world data inputs, eliminating the need for explicit rule design. In this research, we investigated the application of machine learning methods in healthcare, specifically focusing on pregnancy and childbirth risks. The timely identification of risk factors during early pregnancy, along with risk management, mitigation, prevention, and adherence management, can significantly reduce adverse perinatal outcomes and complications for both mother and child. Given the existing burden on medical professionals, clinical decision support systems (CDSSs) can play a role in risk management. However, these systems require high-quality decision support models based on validated medical data that are also clinically interpretable. To develop models for predicting childbirth risks and due dates, we conducted a retrospective analysis of electronic health records from the perinatal Center of the Almazov Specialized Medical Center in Saint-Petersburg, Russia. The dataset, which was exported from the medical information system, consisted of structured and semi-structured data, encompassing a total of 73,115 lines for 12,989 female patients. Our proposed approach, which includes a detailed analysis of predictive model performance and interpretability, offers numerous opportunities for decision support in perinatal care provision. The high predictive performance achieved by our models ensures precise support for both individual patient care and overall health organization management.

摘要

机器学习方法使医疗系统能够使用真实世界的数据输入自动生成数据驱动的决策支持模型,从而无需进行明确的规则设计。在本研究中,我们调查了机器学习方法在医疗保健中的应用,特别关注妊娠和分娩风险。在妊娠早期及时识别风险因素,以及进行风险管理、缓解、预防和依从性管理,可以显著降低母婴围产期不良结局和并发症的发生率。鉴于医疗专业人员目前的负担,临床决策支持系统(CDSS)可以在风险管理中发挥作用。然而,这些系统需要基于经过验证且具有临床可解释性的医学数据的高质量决策支持模型。为了开发预测分娩风险和预产期的模型,我们对俄罗斯圣彼得堡阿尔马佐夫专业医疗中心围产期中心的电子健康记录进行了回顾性分析。该数据集从医疗信息系统导出,由结构化和半结构化数据组成,涵盖12989名女性患者的73115行数据。我们提出的方法包括对预测模型性能和可解释性的详细分析,为围产期护理提供中的决策支持提供了众多机会。我们的模型所实现的高预测性能确保了对个体患者护理和整体健康组织管理的精确支持。

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