Słowińska Monika, Czarnecka Iwona, Czarnecki Robert, Tatara Paulina, Nasierowska-Guttmejer Anna, Lorent Małgorzata, Cierniak Szczepan, Owczarek Witold
Department of Dermatology, Central Clinical Hospital Ministry of Defense, Military Institute of Medicine-National Research Institute, Szaserow 128, 04-141 Warsaw, Poland.
Evimed Medical Centre Ltd., Private Dermatologic Practice, JP Woronicza 16, 02-625 Warsaw, Poland.
Life (Basel). 2023 Jun 12;13(6):1369. doi: 10.3390/life13061369.
Although the role of melanoma risk factors is well documented, their correlation with patients' age is less frequently analyzed.
The analysis was performed among 189 melanoma patients in different age groups, including <30 years, 31-60 years, and >60 years, to investigate the risk factors, topography, and coexistence of morphological features of 209 melanomas (dermoscopic and histopathological).
Among the youngest age group, no correlation with the presence of estimated risk factors was found. The most common dermoscopic pattern was spitzoid and multicomponent asymmetric. The group of middle-aged patients was the most diverse in terms of the occurrence of risk factors, solar lentiginosis, dermoscopic patterns, topography, histological subtypes, and invasiveness of melanomas. The oldest group characterized a strong correlation between solar lentiginosis, NMSC comorbidity, the prevalence of facial melanomas, the dermoscopic pattern of melanoma arising on chronic sun-damaged skin, and regression.
The findings regarding the presence of age-specific features in melanoma patients, especially in the youngest and middle-aged groups, might be helpful for clinicians and to target secondary prevention efforts.
尽管黑色素瘤风险因素的作用已有充分记录，但它们与患者年龄的相关性较少被分析。
对189例不同年龄组的黑色素瘤患者进行分析，年龄组包括<30岁、31 - 60岁和>60岁，以研究209例黑色素瘤（皮肤镜和组织病理学）的风险因素、部位以及形态学特征的共存情况。
在最年轻的年龄组中，未发现与估计的风险因素存在相关性。最常见的皮肤镜模式是梭形和多成分不对称。中年患者组在风险因素的发生、日光性雀斑样痣、皮肤镜模式、部位、组织学亚型以及黑色素瘤的侵袭性方面最为多样。最年长的组表现出日光性雀斑样痣、非黑素瘤皮肤癌合并症、面部黑色素瘤的患病率、慢性日光损伤皮肤出现的黑色素瘤的皮肤镜模式与消退之间存在强相关性。
关于黑色素瘤患者存在年龄特异性特征的研究结果，尤其是在最年轻和中年组中，可能对临床医生以及确定二级预防工作的目标有所帮助。
