Department of Neurosciences, "Iuliu Haţieganu" University of Medicine and Pharmacy, 8 Victor Babeş Street, 400012 Cluj-Napoca, Romania.
Department of Pharmacology, Toxicology and Clinical Pharmacology, "Iuliu Haţieganu" University of Medicine and Pharmacy, 23 Gheorghe Marinescu Street, 400337 Cluj-Napoca, Romania.
Medicina (Kaunas). 2023 Jun 13;59(6):1142. doi: 10.3390/medicina59061142.
: The purpose of this study is to investigate the predictive factors for intrahospital mortality in ischemic stroke patients. We will examine the association between a range of clinical and demographic factors and intrahospital mortality, including age, sex, comorbidities, laboratory values, and medication use. : This retrospective, longitudinal, analytic, observational cohort study included 243 patients over 18 years old with a new ischemic stroke diagnosis who were hospitalized in Cluj-Napoca Emergency County Hospital. Data collected included the patient demographics, baseline characteristics at hospital admission, medication use, carotid artery Doppler ultrasound, as well as cardiology exam, and intrahospital death. : Multivariate logistic regression was used to determine which variables were independently associated with intrahospital death. An NIHSS score > 9 (OR-17.4; < 0.001) and a lesion volume > 22.3 mL (OR-5.8; = 0.003) were found to be associated with the highest risk of death. In contrast antiplatelet treatment (OR-0.349; = 0.04) was associated with lower mortality rates. : Our study identified a high NIHSS score and large lesion volume as independent risk factors for intrahospital mortality in ischemic stroke patients. Antiplatelet therapy was associated with lower mortality rates. Further studies are needed to explore the potential mechanisms underlying these associations and to develop targeted interventions to improve patient outcomes.
: 本研究旨在探讨缺血性脑卒中患者院内死亡的预测因素。我们将检查一系列临床和人口统计学因素与院内死亡率之间的关联,包括年龄、性别、合并症、实验室值和药物使用。 : 这项回顾性、纵向、分析性、观察性队列研究纳入了 243 名年龄在 18 岁以上的新诊断为缺血性脑卒中且在克卢日-纳波卡紧急县医院住院的患者。收集的数据包括患者人口统计学资料、入院时的基线特征、药物使用情况、颈动脉多普勒超声以及心脏科检查和院内死亡情况。 : 多变量逻辑回归用于确定与院内死亡独立相关的变量。NIHSS 评分>9(OR-17.4; <0.001)和病变体积>22.3 mL(OR-5.8; =0.003)与死亡风险最高相关。相反,抗血小板治疗(OR-0.349; =0.04)与较低的死亡率相关。 : 我们的研究确定了高 NIHSS 评分和大病变体积是缺血性脑卒中患者院内死亡的独立危险因素。抗血小板治疗与较低的死亡率相关。需要进一步研究以探讨这些关联的潜在机制,并制定针对性的干预措施以改善患者预后。