钛介导的羧酸酰胺还原为伯胺与硼烷-氨。
Titanium-Mediated Reduction of Carboxamides to Amines with Borane-Ammonia.
机构信息
Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA.
出版信息
Molecules. 2023 Jun 6;28(12):4575. doi: 10.3390/molecules28124575.
Abstract
In this study, the successful titanium tetrachloride-catalyzed reduction of aldehydes, ketones, carboxylic acids, and nitriles with borane-ammonia was extended to the reduction (deoxygenation) of a variety of aromatic and aliphatic pri-, sec- and tert-carboxamides, by changing the stoichiometry of the catalyst and reductant. The corresponding amines were isolated in good to excellent yields, following a simple acid-base workup.
摘要
在这项研究中，成功地将四氯化钛催化的醛、酮、羧酸和腈与氨硼烷的还原反应扩展到了各种芳香族和脂肪族伯、仲和叔羧酸酰胺的还原（脱氧）反应，通过改变催化剂和还原剂的化学计量比。相应的胺在简单的酸碱处理后以良好到优异的收率分离出来。
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