β-环糊精-Ni-MOF-74/还原氧化石墨烯电化学传感器用于芦丁的超灵敏检测的电化学行为。

Electrochemical Behavior of β-Cyclodextrin-Ni-MOF-74/Reduced Graphene Oxide Sensors for the Ultrasensitive Detection of Rutin.

机构信息

Hunan Engineering Laboratory for Preparation Technology of Polyvinyl Alcohol Fiber Material, College of Chemistry and Materials Engineering, Huaihua University, Huaihua 418000, China.

Key Laboratory of Research and Utilization of Ethnomedicinal Plant Resources of Hunan Province, Huaihua University, Huaihua 418008, China.

出版信息

Molecules. 2023 Jun 7;28(12):4604. doi: 10.3390/molecules28124604.

Rutin, as a biological flavonoid glycoside, has very important medicinal value. The accurate and rapid detection of rutin is of great significance. Herein, an ultrasensitive electrochemical rutin sensor based on β-cyclodextrin metal-organic framework/reduced graphene oxide (β-CD-Ni-MOF-74/rGO) was constructed. The obtained β-CD-Ni-MOF-74 was characterized by X-ray diffraction spectroscopy (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), and nitrogen adsorption and desorption. The β-CD-Ni-MOF-74/rGO presented good electrochemical properties benefiting from the large specific surface area and good adsorption enrichment effect of β-CD-Ni-MOF-74 and the good conductivity of rGO. Under optimal conditions for the detection of rutin, the β-CD-Ni-MOF-74/rGO/GCE showed a wider linear range (0.06-1.0 μM) and lower detection limit (LOD, 0.68 nM, (S/N = 3)). Furthermore, the sensor shows good accuracy and stability for the detection of rutin in actual samples.

芦丁作为一种生物类黄酮糖苷，具有非常重要的药用价值。准确、快速地检测芦丁具有重要意义。本研究构建了一种基于β-环糊精金属有机骨架/还原氧化石墨烯（β-CD-Ni-MOF-74/rGO）的超灵敏电化学芦丁传感器。通过 X 射线衍射光谱（XRD）、X 射线光电子能谱（XPS）、扫描电子显微镜（SEM）、傅里叶变换红外光谱（FT-IR）和氮气吸附脱附对所获得的β-CD-Ni-MOF-74 进行了表征。β-CD-Ni-MOF-74/rGO 具有良好的电化学性能，这得益于β-CD-Ni-MOF-74 的大比表面积和良好的吸附富集效果以及 rGO 的良好导电性。在芦丁检测的最佳条件下，β-CD-Ni-MOF-74/rGO/GCE 呈现出更宽的线性范围（0.06-1.0 μM）和更低的检测限（LOD，0.68 nM，（S/N = 3））。此外，该传感器对实际样品中芦丁的检测具有良好的准确性和稳定性。