Competences Center: Interfaces-Tribocorrosion-Electrochemical Systems, Dunarea de Jos University of Galati, 47 Domnească Street, RO-800008 Galati, Romania.
Military Medicine Institute, Street Institutul Medico-Militar 3-5, RO-010919 Bucharest, Romania.
Molecules. 2023 Jun 18;28(12):4837. doi: 10.3390/molecules28124837.
Pure titanium (Ti) is investigated in a pre-clinical study in Hank's biological solution using electrochemical methods, open circuit potential, and electrochemical impedance spectroscopy to highlight the time effect in extreme body conditions, such as inflammatory diseases, on degradability due to corrosion processes occurring on the titanium implant. Electrochemical impedance spectroscopy (EIS) data are presented as Nyquist and Bode plots. The results show the increasing reactivity of titanium implants in the presence of hydrogen peroxide, which is an oxygen-reactive compound that describes inflammatory conditions. The polarization resistance, which results from electrochemical impedance spectroscopy measurements, declined dramatically from the highest value registered in Hank's solution to smaller values registered in all solutions when different concentrations of hydrogen peroxide were tested. The EIS analysis provided insights into titanium's in vitro corrosion behavior as an implanted biomaterial, which could not be solely obtained through potentiodynamic polarization testing.
在汉克氏生物溶液中，采用电化学方法、开路电位和电化学阻抗谱对纯钛（Ti）进行了临床前研究，以突出在炎症等极端身体条件下，由于钛植入物腐蚀过程引起的降解性的时间效应。电化学阻抗谱（EIS）数据以奈奎斯特和波特图表示。结果表明，钛植入物在过氧化氢存在下的反应性增加，过氧化氢是一种描述炎症状态的含氧反应性化合物。极化电阻是通过电化学阻抗谱测量得到的，它从汉克氏溶液中记录的最高值急剧下降到所有溶液中记录的较小值，当测试不同浓度的过氧化氢时。EIS 分析提供了对作为植入生物材料的钛的体外腐蚀行为的深入了解，这不能仅通过动电位极化测试获得。
