Hegna Elena, Rački Valentino, Hero Mario, Papić Eliša, Rožmarić Gloria, Radović Klara, Komen Vita, Bralić Marina, Škifić Marina Legac, Bonifačić David, Tomić Zoran, Perković Olivio, Vuletić Vladimira
Department of Neurology, General Hospital Pula, 52100 Pula, Croatia.
Department of Neurology, Clinical Hospital Center Rijeka, 51000 Rijeka, Croatia.
Pathogens. 2023 Jun 2;12(6):796. doi: 10.3390/pathogens12060796.
Our aim was to determine the frequency and characteristics of neurological post-COVID-19 syndrome and the diagnostic and therapeutic measures that were used for the treatment of these patients. Data were collected for 243 patients examined during the period of 11 May 2021 to 22 June 2022. The inclusion criteria were COVID-19 illness and neurological symptoms associated with COVID-19. The exclusion criteria were non-neurological symptoms, patients who did not suffer from COVID-19, and symptoms that occurred after vaccination against the SARS-CoV-2 virus. Data for 227 patients with neurological post-COVID-19 symptoms were analyzed. Most patients presented with multiple symptoms, most often headache, cognitive impairment, loss of smell, paresthesia, fatigue, dizziness, and insomnia. Patients were most often referred for consultative examinations, neuroradiological imaging, and EEG. The therapy was mostly symptomatic. Most patients had no change in their symptoms on follow-up visits (53.21%), while positive outcome was found in 44.95% of patients. This study found that neurological post-COVID-19 syndrome appears to be more common in women, and generally, the most common symptoms are headache and cognitive impairment. The gender distribution of symptoms was clearly visible and should be further investigated. There is a need for longitudinal follow-up studies to better understand the disease dynamic.
我们的目的是确定新冠后神经综合征的发生率和特征,以及用于治疗这些患者的诊断和治疗措施。收集了2021年5月11日至2022年6月22日期间接受检查的243例患者的数据。纳入标准为新冠疾病以及与新冠相关的神经症状。排除标准为非神经症状、未患新冠的患者以及接种新冠病毒疫苗后出现的症状。对227例有新冠后神经症状的患者的数据进行了分析。大多数患者表现出多种症状,最常见的是头痛、认知障碍、嗅觉丧失、感觉异常、疲劳、头晕和失眠。患者最常被转诊进行咨询检查、神经放射成像和脑电图检查。治疗主要是对症治疗。大多数患者在随访时症状无变化(53.21%),而44.95%的患者有阳性结果。本研究发现,新冠后神经综合征在女性中似乎更常见,一般来说,最常见的症状是头痛和认知障碍。症状的性别分布明显,应进一步研究。需要进行纵向随访研究以更好地了解疾病动态。