Pineda-Álvarez Ramón Andrés, Flores-Avila Carolina, Medina-Torres Luis, Gracia-Mora Jesús, Escobar-Chávez José Juan, Leyva-Gómez Gerardo, Shahbazi Mohammad-Ali, Bernad-Bernad María Josefa
Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Cto. Exterior S/N, Coyoacán, Ciudad de México 04510, Mexico.
Facultad de Estudios Superiores Cuautitlán, Unidad de Investigación Multidisciplinaria-L12 (Sistemas Transdérmicos), Universidad Nacional Autónoma de México, Carretera Cuautitlán-Teoloyucan, km 2.5 San Sebastián Xhala, Cuautitlán Izcalli 54714, Mexico.
Pharmaceutics. 2023 May 31;15(6):1634. doi: 10.3390/pharmaceutics15061634.
A healing material must have desirable characteristics such as maintaining a physiological environment, protective barrier-forming abilities, exudate absorption, easy handling, and non-toxicity. Laponite is a synthetic clay with properties such as swelling, physical crosslinking, rheological stability, and drug entrapment, making it an interesting alternative for developing new dressings. This study evaluated its performance in lecithin/gelatin composites (LGL) as well as with the addition of maltodextrin/sodium ascorbate mixture (LGL MAS). These materials were applied as nanoparticles, dispersed, and prepared by using the gelatin desolvation method-eventually being turned into films via the solvent-casting method. Both types of composites were also studied as dispersions and films. Dynamic Light Scattering (DLS) and rheological techniques were used to characterize the dispersions, while the films' mechanical properties and drug release were determined. Laponite in an amount of 8.8 mg developed the optimal composites, reducing the particulate size and avoiding the agglomeration by its physical crosslinker and amphoteric properties. On the films, it enhanced the swelling and provided stability below 50 °C. Moreover, the study of drug release in maltodextrin and sodium ascorbate from LGL MAS was fitted to first-order and Korsmeyer-Peppas models, respectively. The aforementioned systems represent an interesting, innovative, and promising alternative in the field of healing materials.
一种愈合材料必须具备理想的特性,如维持生理环境、形成保护屏障的能力、吸收渗出液、易于操作和无毒。锂皂石是一种合成粘土,具有膨胀、物理交联、流变稳定性和药物包封等特性,使其成为开发新型敷料的一个有趣选择。本研究评估了其在卵磷脂/明胶复合材料(LGL)以及添加麦芽糊精/抗坏血酸钠混合物(LGL MAS)中的性能。这些材料以纳米颗粒形式应用,通过明胶去溶剂化方法分散并制备,最终通过溶剂浇铸法制成薄膜。两种复合材料也作为分散体和薄膜进行了研究。使用动态光散射(DLS)和流变技术对分散体进行表征,同时测定薄膜的机械性能和药物释放。8.8毫克锂皂石形成了最佳复合材料,通过其物理交联剂和两性性质减小了颗粒尺寸并避免了团聚。在薄膜上,它增强了膨胀并在50°C以下提供了稳定性。此外,对LGL MAS中麦芽糊精和抗坏血酸钠的药物释放研究分别符合一级模型和Korsmeyer-Peppas模型。上述系统在愈合材料领域代表了一种有趣、创新且有前景的选择。