Abruzzo Angela, Cappadone Concettina, Sallustio Valentina, Picone Giovanna, Rossi Martina, Nicoletta Fiore Pasquale, Luppi Barbara, Bigucci Federica, Cerchiara Teresa
Department of Pharmacy and Biotechnology, University of Bologna, Via San Donato 19/2, 40127 Bologna, Italy.
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata, Rende, Italy.
Pharmaceutics. 2021 Aug 3;13(8):1192. doi: 10.3390/pharmaceutics13081192.
The selection of an appropriate dressing for each type of wound is a very important procedure for a faster and more accurate healing process. So, the aim of this study was to develop innovative Spanish Broom and flax wound dressings, as alternatives to cotton used as control, with polymeric films containing glycyrrhetinic acid (GA) to promote wound-exudate absorption and the healing process. The different wound dressings were prepared by a solvent casting method, and characterized in terms of drug loading, water uptake, and in vitro release. Moreover, biological studies were performed to evaluate their biocompatibility and wound-healing efficacy. Comparing the developed wound dressings, Spanish Broom dressings with GA-loaded sodium hyaluronate film had the best functional properties, in terms of hydration ability and GA release. Moreover, they showed a good biocompatibility, determining a moderate induction of cell proliferation and no cytotoxicity. In addition, the wound-healing test revealed that the Spanish Broom dressings promoted cell migration, further facilitating the closure of the wound.
为实现更快、更准确的愈合过程，为每种类型的伤口选择合适的敷料是一个非常重要的步骤。因此，本研究的目的是开发创新的西班牙金雀花和亚麻伤口敷料，作为对照使用的棉花的替代品，其采用含有甘草次酸（GA）的聚合物薄膜来促进伤口渗出液吸收和愈合过程。通过溶剂浇铸法制备不同的伤口敷料，并对其载药量、吸水性和体外释放进行表征。此外，还进行了生物学研究以评估其生物相容性和伤口愈合效果。比较所开发的伤口敷料，含有负载GA的透明质酸钠薄膜的西班牙金雀花敷料在水合能力和GA释放方面具有最佳的功能特性。此外，它们表现出良好的生物相容性，能适度诱导细胞增殖且无细胞毒性。此外，伤口愈合测试表明，西班牙金雀花敷料促进细胞迁移，进一步促进伤口闭合。
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