Hussien Mostafa A, Ashour Gadeer R, Albukhari Soha M, Saleh Tamer S, Hussein Mahmoud A
Chemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia.
Department of Chemistry, Faculty of Applied Sciences, Umm Al Qura University, P.O. Box 24451, Makkah 21955, Saudi Arabia.
Polymers (Basel). 2023 Jun 13;15(12):2662. doi: 10.3390/polym15122662.
This research sought to synthesize a new set of heteroaromatic thiazole-based polyurea derivatives with sulfur links in the polymers' main chains, which were denoted by the acronyms PU. Using pyridine as a solvent, a diphenylsulfide-based aminothiazole monomer (M2) was polymerized via solution polycondensation with varied aromatic, aliphatic, and cyclic diisocyanates. Typical characterization methods were used to confirm the structures of the premonomer, monomer, and fully generated polymers. The XRD results revealed that aromatic-based polymers had higher crystallinity than aliphatic and cyclic derivatives. SEM was used to visualize the surfaces of PU, PU, and PU, revealing spongy and porous shapes, shapes resembling wooden planks and sticks, and shapes resembling coral reefs with floral shapes at various magnifications. The polymers demonstrated thermal stability. The numerical results for PDTmax are listed in the following order, ranked from lowest to highest: PU < PU < PU < PU < PU. The values for the aliphatic-based derivatives (PU and PU) were lower than those for the aromatic-based ones (616, 655, and 665 °C). PU showed the greatest inhibitory impact against the bacteria and fungi under investigation. In addition, PU and PU demonstrated antifungal activities that, in contrast with the other products, were on the lower end of the spectrum. Furthermore, the intended polymers were also tested for the presence of the proteins 1KNZ, 1JIJ, and 1IYL, which are frequently utilized as model organisms for (Gram-negative bacteria), (Gram-positive bacteria), and (fungal pathogens). This study's findings are consistent with the outcomes of the subjective screening.
本研究旨在合成一组新的基于杂芳族噻唑的聚脲衍生物，这些衍生物在聚合物主链中带有硫键，其简称为PU。以吡啶为溶剂，通过溶液缩聚使基于二苯硫醚的氨基噻唑单体（M2）与各种芳族、脂肪族和环状二异氰酸酯聚合。使用典型的表征方法来确认预聚物、单体和完全生成的聚合物的结构。X射线衍射结果表明，基于芳族的聚合物比脂肪族和环状衍生物具有更高的结晶度。扫描电子显微镜用于观察PU、PU和PU的表面，在不同放大倍数下分别呈现出海绵状和多孔状、类似木板和木棍的形状以及类似带有花状的珊瑚礁的形状。这些聚合物表现出热稳定性。PDTmax的数值结果按以下顺序列出，从最低到最高排列：PU < PU < PU < PU < PU。基于脂肪族的衍生物（PU和PU）的值低于基于芳族的衍生物（616、655和665℃）。PU对所研究的细菌和真菌显示出最大的抑制作用。此外，PU和PU表现出抗真菌活性，与其他产品相比，处于该活性范围的较低端。此外，还对目标聚合物进行了蛋白质1KNZ、1JIJ和1IYL的检测，这些蛋白质经常被用作（革兰氏阴性菌）、（革兰氏阳性菌）和（真菌病原体）的模式生物。本研究的结果与主观筛选的结果一致。
