Narumi S, Kiyota Y, Nagaoka A
Pharmacol Biochem Behav. 1986 Jun;24(6):1729-31. doi: 10.1016/0091-3057(86)90512-5.
Cerebral embolization was produced by injecting microspheres into the left internal carotid artery in rats. In these embolized rats, passive avoidance response was impaired at early stages after the embolization (3 days, 1 and 2 weeks), but 4 to 8 weeks later, recovery was achieved. A reduction in the activities of choline acetyltransferase (CAT) in the left side of the occipital cortex and hippocampus was observed in parallel with the impairment of learning behavior. These results suggest that impairments in the septo-hippocampal cholinergic pathways are likely to be closely related with the behavioral impairment in these rats.
通过向大鼠左颈内动脉注射微球来制造脑栓塞。在这些栓塞大鼠中，栓塞后早期（3天、1周和2周）被动回避反应受损，但4至8周后恢复。枕叶皮质和海马左侧胆碱乙酰转移酶（CAT）活性降低与学习行为受损同时出现。这些结果表明，隔区-海马胆碱能通路的损伤可能与这些大鼠的行为损伤密切相关。
