Kiyota Y, Miyamoto M, Nagaoka A, Nagawa Y
Pharmacol Biochem Behav. 1986 Mar;24(3):687-92. doi: 10.1016/0091-3057(86)90575-7.
The effects of cerebral embolization, produced by injecting microspheres into the left internal carotid artery, on passive and active avoidance tasks and water filled multiple T-maze task, were studied in male Wistar rats. The rats with cerebral embolization were markedly impaired acquisition and retention of the one-trial passive avoidance response. The impairment depended on the number of microspheres injected and continued for 2 weeks. The cerebral embolized rats were also impaired acquisition of two-way active avoidance response in a shuttle box. These impairments are not due to decrease in shock sensitivity, because there was no significant change in the flinch-jump threshold. The embolized rats also exhibited a significant disturbance in performance of water filled multiple T-maze learning. These results suggest that rats with cerebral embolization are impaired in three different types of learning tasks, and may be useful as an animal model for the vascular type of dementia.
通过向雄性Wistar大鼠的左颈内动脉注射微球来制造脑栓塞，研究其对被动和主动回避任务以及水填充多重T迷宫任务的影响。患有脑栓塞的大鼠在单次被动回避反应的习得和保持方面明显受损。这种损害取决于注射的微球数量，并持续2周。脑栓塞大鼠在穿梭箱中双向主动回避反应的习得也受到损害。这些损害并非由于休克敏感性降低，因为退缩跳跃阈值没有显著变化。栓塞大鼠在水填充多重T迷宫学习的表现中也表现出明显的紊乱。这些结果表明，患有脑栓塞的大鼠在三种不同类型的学习任务中受损，可能作为血管性痴呆类型的动物模型。
