Grzęda Dominik, Węgrzyk Grzegorz, Nowak Adriana, Idaszek Joanna, Szczepkowski Leonard, Ryszkowska Joanna
Faculty of Materials Science and Engineering, Warsaw University of Technology, Wołoska 141, 02-507 Warsaw, Poland.
Department of Environmental Biotechnology, Lodz University of Technology, Wolczanska 171/173, 90-530 Lodz, Poland.
Polymers (Basel). 2023 Jun 20;15(12):2754. doi: 10.3390/polym15122754.
Polyurethane foams are widely used in biomedical applications due to their desirable mechanical properties and biocompatibility. However, the cytotoxicity of its raw materials can limit their use in certain applications. In this study, a group of open-cell polyurethane foams were investigated for their cytotoxic properties as a function of the isocyanate index, a critical parameter in the synthesis of polyurethanes. The foams were synthesized using a variety of isocyanate indices and characterized for their chemical structure and cytotoxicity. This study indicates that the isocyanate index highly influences the chemical structure of polyurethane foams, also causing changes in cytotoxicity. These findings have important implications for designing and using polyurethane foams as composite matrices in biomedical applications, as careful consideration of the isocyanate index is necessary to ensure biocompatibility.
聚氨酯泡沫因其理想的机械性能和生物相容性而广泛应用于生物医学领域。然而，其原材料的细胞毒性可能会限制它们在某些应用中的使用。在本研究中，研究了一组开孔聚氨酯泡沫的细胞毒性特性，该特性是异氰酸酯指数的函数，而异氰酸酯指数是聚氨酯合成中的一个关键参数。使用多种异氰酸酯指数合成了泡沫，并对其化学结构和细胞毒性进行了表征。本研究表明，异氰酸酯指数对聚氨酯泡沫的化学结构有很大影响，也会导致细胞毒性的变化。这些发现对于在生物医学应用中设计和使用聚氨酯泡沫作为复合基质具有重要意义，因为必须仔细考虑异氰酸酯指数以确保生物相容性。
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