White R E, Carrier G O
Pharmacology. 1986;33(1):34-8. doi: 10.1159/000138197.
Diabetes mellitus is known to produce alterations in vascular reactivity. In the present study we have examined the effects of short-term diabetes on histamine-induced relaxation of isolated mesenteric arteries, and the role of the endothelial cell layer in this response. Removal of the endothelium completely abolished the histamine relaxation effect in both diabetic and age-matched control rats. In contrast, vessels isolated from streptozotocin-diabetic rats were supersensitive to histamine, and this relaxation was mediated only through the H1-receptors. The present findings suggest that histamine-induced relaxation of rat mesenteric arteries is dependent upon endothelial cell processes which are enhanced in arteries from STZ-diabetic rats.
已知糖尿病会引起血管反应性改变。在本研究中，我们检测了短期糖尿病对组胺诱导的离体肠系膜动脉舒张的影响，以及内皮细胞层在该反应中的作用。去除内皮后，糖尿病大鼠和年龄匹配的对照大鼠的组胺舒张效应均完全消失。相反，从链脲佐菌素诱导的糖尿病大鼠分离的血管对组胺超敏感，且这种舒张仅通过H1受体介导。目前的研究结果表明，组胺诱导的大鼠肠系膜动脉舒张依赖于内皮细胞过程，而在链脲佐菌素诱导的糖尿病大鼠的动脉中这些过程增强。
