Ferrell F, Dreith A Z
Physiol Behav. 1986;37(2):337-43. doi: 10.1016/0031-9384(86)90243-x.
Appetite for solutions of 0.01 M-0.1 M calcium chloride or calcium lactate were assessed using the two-bottle choice technique in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) normotensive rats fed calcium replete diets. SHR exhibited a marginally increased preference for calcium chloride and a significantly increased preference for calcium lactate (p less than 0.02). In SHR, but not in WKY, 28 days of calcium exposure via the preference test solutions significantly affected systolic blood pressure (p less than 0.03). The group of SHR ingesting calcium chloride had a lower mean systolic blood pressure, and that ingesting calcium lactate had a higher mean systolic blood pressure than the control group receiving no exposure to calcium in preference tests. Blood pressures of individual rats, however, were not related to cumulative milliequivalents of Ca consumed, body weight, whole blood or serum ionized Ca, K or Na concentrations, or total serum calcium. Strain differences in chemosensory sensitivity might play a role in mediating the enhanced self-selection of calcium by SHR.
在喂食充足钙饮食的自发性高血压（SHR）大鼠和Wistar-Kyoto（WKY）正常血压大鼠中，采用双瓶选择技术评估了对0.01 M - 0.1 M氯化钙或乳酸钙溶液的偏好。SHR对氯化钙的偏好略有增加，对乳酸钙的偏好显著增加（p < 0.02）。在SHR中，而非WKY中，通过偏好测试溶液进行28天的钙暴露显著影响收缩压（p < 0.03）。在偏好测试中，摄入氯化钙的SHR组平均收缩压较低，摄入乳酸钙的SHR组平均收缩压高于未接触钙的对照组。然而，个体大鼠的血压与消耗的钙累积毫当量、体重、全血或血清离子化钙、钾或钠浓度或总血清钙无关。化学感觉敏感性的品系差异可能在介导SHR对钙的增强自我选择中起作用。
