28种小鼠品系对氯化钠、氯化钾、氯化钙和氯化铵溶液的自愿摄入量。
Voluntary consumption of NaCl, KCl, CaCl2, and NH4Cl solutions by 28 mouse strains.
作者信息
Bachmanov Alexander A, Beauchamp Gary K, Tordoff Michael G
机构信息
Monell Chemical Senses Center, 3500 Market St., Philadelphia, PA 19104, USA.
出版信息
Behav Genet. 2002 Nov;32(6):445-57. doi: 10.1023/a:1020832327983.
Male mice from 28 inbred strains (129P3/J, A/J, AKR/J, BALB/cByJ, BUB/BnJ, C3H/HeJ, C57BL/6J, C57L/J, CAST/Ei, CBA/J, CE/J, DBA/2J, FVB/NJ, I/LnJ, KK/H1J, LP/J, NOD/LtJ, NZB/B1NJ, P/J, PL/J, RBF/DnJ, RF/J, RIIIS/J, SEA/GnJ, SJL/J, SM/J, SPRET/Ei, and SWR/J) were tested with NaCl (75-450 mM), KCl (30-300 mM), CaCl2 (3-100 mM), and NH4Cl (10-300 mM) solutions using two-bottle preference tests with water as the second choice. For each mineral, there was a wide range of strain variation in solution intakes and preferences. This variation had a substantial genetic component as assessed using heritability estimates. In most cases, the strain means were continuously distributed; however, strains with deviating high or low intakes or preferences were also observed. The associations among the responses to different minerals were only modest, suggesting distinct genetic controls of sodium, potassium, calcium, and ammonium consumption. These results provide a valuable resource for investigators who wish to identify genes involved in the regulation of mineral consumption and balance.
使用双瓶偏好测试，以水作为第二选择，对来自28个近交系（129P3/J、A/J、AKR/J、BALB/cByJ、BUB/BnJ、C3H/HeJ、C57BL/6J、C57L/J、CAST/Ei、CBA/J、CE/J、DBA/2J、FVB/NJ、I/LnJ、KK/H1J、LP/J、NOD/LtJ、NZB/B1NJ、P/J、PL/J、RBF/DnJ、RF/J、RIIIS/J、SEA/GnJ、SJL/J、SM/J、SPRET/Ei和SWR/J）的雄性小鼠进行了NaCl（75 - 450 mM）、KCl（30 - 300 mM）、CaCl2（3 - 100 mM）和NH4Cl（10 - 300 mM）溶液测试。对于每种矿物质，溶液摄入量和偏好存在广泛的品系差异。使用遗传力估计评估，这种差异具有很大的遗传成分。在大多数情况下，品系均值呈连续分布；然而，也观察到摄入量或偏好偏离高或低的品系。对不同矿物质的反应之间的关联仅适度，表明钠、钾、钙和铵消耗存在不同的遗传控制。这些结果为希望鉴定参与矿物质消耗和平衡调节的基因的研究人员提供了宝贵资源。
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