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卡立普嗪治疗精神分裂症、躁狂症、双相抑郁症和单相抑郁症:疗效综述

Cariprazine for Treating Schizophrenia, Mania, Bipolar Depression, and Unipolar Depression: A Review of Its Efficacy.

作者信息

Tarzian Martin, Ndrio Mariana, Kaja Srujan, Beason Elisabeth, Fakoya Adegbenro O

机构信息

Psychiatry, University of Medicine and Health Sciences, Basseterre, KNA.

Psychiatry and Behavioral Sciences, University of Medicine and Health Sciences, Basseterre, KNA.

出版信息

Cureus. 2023 May 21;15(5):e39309. doi: 10.7759/cureus.39309. eCollection 2023 May.

Abstract

This drug review presents a comprehensive review of Cariprazine, a medication that received FDA approval in 2015 for treating schizophrenia and bipolar disorder. The paper begins by exploring Cariprazine's mechanism of action, which involves modulating dopamine and serotonin receptors. Additionally, the review assesses Cariprazine's metabolic profile and notes its low potential for weight gain and metabolic side effects. The study examines Cariprazine's efficacy and safety in treating various psychiatric disorders, such as schizophrenia, bipolar maintenance, mania, and bipolar depression. A meticulous analysis of clinical trials is included, demonstrating Cariprazine's potential advantages over existing medications used for these disorders. Additionally, the review covers Cariprazine's recent approval as an adjuvant treatment for unipolar depression. Furthermore, the paper examines the limitations of Cariprazine, such as the absence of head-to-head trials comparing it to other commonly used medications for these disorders. The paper concludes by emphasizing the need for more research to establish Cariprazine's position in treating schizophrenia and bipolar disorder and determine its comparative effectiveness with other available treatments.

摘要

本药物综述对卡立普嗪进行了全面回顾,该药物于2015年获得美国食品药品监督管理局(FDA)批准,用于治疗精神分裂症和双相情感障碍。本文首先探讨了卡立普嗪的作用机制,其涉及调节多巴胺和5-羟色胺受体。此外,该综述评估了卡立普嗪的代谢特征,并指出其体重增加和代谢副作用的可能性较低。该研究考察了卡立普嗪在治疗各种精神疾病(如精神分裂症、双相情感障碍维持期、躁狂症和双相抑郁)方面的疗效和安全性。其中包括对临床试验的细致分析,证明了卡立普嗪相对于用于这些疾病的现有药物的潜在优势。此外,该综述涵盖了卡立普嗪最近被批准作为单相抑郁症辅助治疗药物的情况。此外,本文还探讨了卡立普嗪的局限性,例如缺乏将其与用于这些疾病的其他常用药物进行对比的头对头试验。本文最后强调,需要进行更多研究以确立卡立普嗪在治疗精神分裂症和双相情感障碍中的地位,并确定其与其他可用治疗方法相比的相对有效性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02b8/10292137/c3d33baa81c9/cureus-0015-00000039309-i01.jpg

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