Yuan Chen, Zhang Yixiong
Department of Nursing, Nanjing University of Chinese Medicine, Nanjing, China.
Int J Nurs Knowl. 2024 Apr;35(2):177-185. doi: 10.1111/2047-3095.12437. Epub 2023 Jun 28.
To perform a meta-analysis identifying the modifiable risk factors of cognitive frailty in the elderly.
We systematically searched databases including PubMed, EMBASE, China National Knowledge Infrastructure, China Science and Technology Journal Database, Wanfang Data Knowledge Service Platform from January 01, 2017 to March 26, 2022. Quantitative, original research reporting associated factors were included.
7,854 records in total were identified, of which 14 articles (1 prospective, 13 cross-sectional) with 36 factors were included. Studies on cognitive frailty included 20,390 community-dwellers (≥60 years) from three countries. Meta-analysis indicated that depression [OR = 3.60, 95%CI (2.25,5.78), p < 0.01] and sleep problems [OR = 2.36, 95%CI (1.62,3.43), p < 0.01] were associated with cognitive frailty.
Effective interventions targeting depression and sleep problems may lower the risk of cognitive frailty in the community seniors but need further study in high-quality, prospective studies.
Building on previous work, the objectives of this systematic review and meta-analysis were to explore potential modifiable risk factors for cognitive frailty in community-dwelling older adults, which is expected to throw light on the prevention of cognitive frailty.
进行一项荟萃分析，以确定老年人认知衰弱的可改变风险因素。
我们系统检索了包括PubMed、EMBASE、中国知网、中国科技期刊数据库、万方数据知识服务平台在内的数据库，检索时间为2017年1月1日至2022年3月26日。纳入定量的、报告相关因素的原始研究。
共识别出7854条记录，其中纳入了14篇文章（1篇前瞻性研究，13篇横断面研究），涉及36个因素。关于认知衰弱的研究纳入了来自三个国家的20390名社区居民（≥60岁）。荟萃分析表明，抑郁[比值比（OR）=3.60，95%置信区间（CI）（2.25，5.78），p<0.01]和睡眠问题[OR=2.36，95%CI（1.62，3.43），p<0.01]与认知衰弱相关。
针对抑郁和睡眠问题的有效干预措施可能会降低社区老年人认知衰弱的风险，但需要在高质量的前瞻性研究中进一步探讨。
基于以往的研究工作，本系统评价和荟萃分析的目的是探索社区居住老年人认知衰弱的潜在可改变风险因素，有望为认知衰弱的预防提供思路。
