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DCK confers sensitivity of DCTD-positive cancer cells to oxidized methylcytidines.

作者信息

Zhao Ya-Hui, Jiang Wei, Gao Hai, Pang Guo-Zheng, Wu Yu-Shuang, Wang Yuan-Xian, Sheng Meng-Yao, Xie Jia-Ying, Wu Wan-Ling, Ji Zhi-Jian, Du Ya-Rui, Zhang Lei, Wang Xiao-Qin, Walsh Colum P, Jiang Hai, Xu Guo-Liang, Zhou Dan

机构信息

Shanghai Key Laboratory of Medical Epigenetics, Laboratory of Cancer Epigenetics, Institutes of Biomedical Sciences, Medical College of Fudan University, Chinese Academy of Medical Sciences (RU069), Shanghai 200032, China.

State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China.

出版信息

Protein Cell. 2023 Jun 28;14(7):532-537. doi: 10.1093/procel/pwac028.

DOI:10.1093/procel/pwac028
PMID:37378658
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10305735/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/870c/10305735/4e6d1e3256c9/pwac028_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/870c/10305735/2ab7ac02f7be/pwac028_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/870c/10305735/4e6d1e3256c9/pwac028_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/870c/10305735/2ab7ac02f7be/pwac028_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/870c/10305735/4e6d1e3256c9/pwac028_fig2.jpg

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Science. 2021 Apr 9;372(6538):156-165. doi: 10.1126/science.abb4542.
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A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress.一部分含铂化疗药物通过诱导核糖体生物合成应激来杀死细胞。
Nat Med. 2017 Apr;23(4):461-471. doi: 10.1038/nm.4291. Epub 2017 Feb 27.
3
Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras.
一项CRISPR-Cas9筛选揭示了细胞对阿扎胞苷反应的遗传决定因素。
EMBO Rep. 2025 Mar;26(6):1528-1565. doi: 10.1038/s44319-025-00385-w. Epub 2025 Feb 10.
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A multiomics approach reveals RNA dynamics promote cellular sensitivity to DNA hypomethylation.一种多组学方法揭示RNA动态变化促进细胞对DNA低甲基化的敏感性。
Sci Rep. 2024 Oct 29;14(1):25940. doi: 10.1038/s41598-024-77314-9.
基因必需性分析揭示基因网络以及与致癌性Ras的合成致死相互作用。
Cell. 2017 Feb 23;168(5):890-903.e15. doi: 10.1016/j.cell.2017.01.013. Epub 2017 Feb 2.
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CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer.CDA 指导表观遗传核苷的代谢，揭示癌症治疗的新窗口。
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