Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
Athens Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
J Vet Diagn Invest. 2023 Sep;35(5):573-576. doi: 10.1177/10406387231184416. Epub 2023 Jun 29.
Neurologic disease associated with migration of plant material is reported infrequently in dogs. Here we describe meningoencephalomyelitis associated with foreign plant material in a 2-y-old castrated male West Highland White Terrier dog with acute neck pain. Magnetic resonance imaging revealed spinal meningeal contrast enhancement. Although clinical signs improved after treatment with steroids, the dog was readmitted for further evaluation 3-mo later and was euthanized after generalized epileptic seizures. Autopsy findings consisted of coalescing, pus-filled, neuroparenchymal cavitations surrounded by hemorrhage in the left caudal colliculus and rostral left cerebellar hemisphere. Histologically, lesions consisted of necrosis and suppuration, which surrounded a 1 × 2-mm foreign body morphologically consistent with plant material and clusters of gram-positive bacterial cocci. Affected areas were surrounded by reactive astrocytes, fibrous connective tissue, and mixed inflammatory infiltrates. Areas of hemorrhage and infiltration by neutrophils and foamy macrophages with fibrinoid change of small capillaries were observed in the adjacent neuroparenchyma. The inflammation extended to the perivascular spaces in the leptomeninges (mesencephalon, cerebellum, and brainstem, and spinal cord) and spinal central canal. Anaerobic bacterial culture of frozen samples of cerebellum yielded heavy growth of .
与植物材料迁移相关的神经疾病在犬中报道较少。在这里，我们描述了一只 2 岁雄性去势西高地白梗犬与急性颈部疼痛相关的脑膜脑脊髓炎，与外来植物材料有关。磁共振成像显示脊髓脑膜对比增强。尽管在类固醇治疗后临床症状有所改善，但该犬 3 个月后因进一步评估而再次入院，并在全身性癫痫发作后被安乐死。尸检结果包括左尾状丘脑和左小脑半球头侧融合、充满脓液的神经实质空洞，周围伴有出血。组织学上，病变包括坏死和化脓，周围是一个 1×2mm 的异物，形态上与植物材料一致，还有革兰阳性球菌簇。受影响的区域被反应性星形胶质细胞、纤维结缔组织和混合炎症浸润所包围。在邻近的神经实质中观察到出血区和中性粒细胞及泡沫状巨噬细胞浸润，伴有小毛细血管纤维蛋白样变性。炎症延伸到软脑膜（中脑、小脑和脑干以及脊髓）和脊髓中央管的血管周围间隙。小脑冷冻样本的厌氧细菌培养物产生了大量的.
