[25-64岁男性开放人群中的昼夜节律基因与睡眠障碍（世界卫生组织莫尼卡-心理社会项目下的一项流行病学研究）]
[Genes of the circadian rhythm and sleep disorders in an open population of men aged 25-64 years (an epidemiological study under the WHO MONICA-PSYCHOSOCIAL program)].
作者信息
Gafarov V V, Gromova E A, Tripelgorn A N, Gagulin I V, Maksimov V N, Gafarova A V
机构信息
Research Institute of Therapy and Preventive Medicine - branch of the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Collaborative Laboratory of Epidemiology of Cardiovascular Diseases, Novosibirsk, Russia.
出版信息
Zh Nevrol Psikhiatr Im S S Korsakova. 2023;123(6):88-93. doi: 10.17116/jnevro202312306188.
OBJECTIVE
To study an effect of polymorphisms of genes encoding circadian rhythm proteins () on sleep disorders in men aged 25-64 years.
MATERIAL AND METHODS
The general examination was carried out according to standard methods included in the WHO MONICA-psychosocial (MOPSY) program. The standard Jenkins questionnaire was used to study sleep disorders. Genotyping of the polymorphisms of was carried out.
RESULTS
Carriers of the genotype of rs2412646 were more likely to think that their sleep was «satisfactory» or «bad». Carriers of the genotype of rs2278749 were more likely to experience disturbing dreams, they woke up tired and exhausted. Carriers of the genotype of rs934945 were more likely (25%) to wake up two or more times a night, in general, from 4 to 7 times a week. In the population, the and genotypes of rs4851377 were significantly more common in individuals with 7-hour sleep (50% and 53.3%, respectively).
CONCLUSION
An association of certain polymorphisms of t with sleep disorders was found.
目的
研究编码昼夜节律蛋白的基因多态性对25 - 64岁男性睡眠障碍的影响。
材料与方法
按照世界卫生组织莫妮卡 - 心理社会（MOPSY）项目中包含的标准方法进行全面检查。使用标准的詹金斯问卷研究睡眠障碍。对相关基因多态性进行基因分型。
结果
rs2412646的特定基因型携带者更倾向于认为他们的睡眠是“令人满意的”或“不好的”。rs2278749的特定基因型携带者更容易经历多梦，醒来时感到疲惫不堪。rs934945的特定基因型携带者更有可能（25%）每晚醒来两次或更多次，总体而言，每周4至7次。在总体人群中，rs4851377的特定基因型在睡眠时间为7小时的个体中显著更常见（分别为50%和53.3%）。
结论
发现了特定基因多态性与睡眠障碍之间的关联。
Zotero 插件