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酗酒者白喉暴发期间的抗毒素抗体水平与疾病转归

Antitoxin antibody levels and the outcome of illness during an outbreak of diphtheria among alcoholics.

作者信息

Björkholm B, Böttiger M, Christenson B, Hagberg L

出版信息

Scand J Infect Dis. 1986;18(3):235-9. doi: 10.3109/00365548609032332.

DOI:10.3109/00365548609032332
PMID:3738434
Abstract

During an outbreak of diphtheria among alcoholics in Göteborg, Sweden, a study was made of the diphtheria-antitoxin antibodies in serum samples from 8 clinical cases and 36 carriers of toxin-producing Corynebacterium diphtheriae. 33/36 carriers were antibody-positive and had antitoxin titres greater than 0.01 IU/ml, a level which is regarded as relative protective, while only 1/8 clinical cases had such a titre. This patient presented a mild illness with no complications. The results of the study of this outbreak stress the importance of maintaining adequate antibody levels against diphtheria in highly developed societies.

摘要

在瑞典哥德堡酗酒者中爆发白喉期间,对8例临床病例和36例产毒素白喉棒状杆菌携带者的血清样本中的白喉抗毒素抗体进行了研究。36名携带者中有33名抗体呈阳性,抗毒素滴度大于0.01 IU/ml,这一水平被视为具有相对保护作用,而8例临床病例中只有1例有这样的滴度。该患者病情较轻,无并发症。这次疫情的研究结果强调了在高度发达的社会中维持足够的抗白喉抗体水平的重要性。

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