从深海来源 sp. HDN20-1401 中发现的新型环状二肽。

New cyclic dipeptide discovered from deep-sea derived sp. HDN20-1401.

机构信息

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.

Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao, China.

出版信息

Nat Prod Res. 2024 Sep;38(18):3231-3236. doi: 10.1080/14786419.2023.2227754. Epub 2023 Jun 29.

DOI:10.1080/14786419.2023.2227754

PMID:37384587

Abstract

A new alkaloid named aspergilalkaloid A () with pyridoindole hydroxymethyl piperazine dione structure along with six known compounds were isolated from deep-sea derived fungus sp. HDN20-1401. The structure including absolute configuration was elucidated by extensive NMR analyses, HRESIMS, ECD calculation, and theoretical NMR calculation with DP4+ analysis. All isolated compounds were tested for antimicrobial and anticancer activity. Aspergilalkaloid A () showed inhibitive activity against with MIC value of 12.5 M and weak activity against MRCNS.

摘要

从深海来源真菌 Aspergillus sp. HDN20-1401 中分离得到一种新的生物碱，命名为aspergilalkaloid A ()，具有吡啶并吲哚羟甲基哌嗪二酮结构，以及六个已知化合物。通过广泛的 NMR 分析、HRESIMS、ECD 计算和 DP4+分析的理论 NMR 计算，阐明了包括绝对构型在内的结构。所有分离得到的化合物均进行了抗微生物和抗癌活性测试。 Aspergilalkaloid A () 对具有抑制活性，MIC 值为 12.5 μM，对 MRCNS 表现出较弱的活性。