Widgren S
Schweiz Med Wochenschr. 1986 Jul 8;116(27-28):918-24.
The lesions of pulmonary muscular arteries of 9 female patients who died of pulmonary hypertensive disease between 9 and 17 years after intake of an anorexigenic drug, aminorex fumarate, have been examined by various methods (light microscopy, numeration of lesions, morphometry). The numeration of lesions showed the predominance of fibrotic and dilatation lesions, but also the presence of active lesions (intimal hyperplasia, plexiform lesions). Morphometry revealed an increase in mean thickness of the media, compared to that of the arteries of controls or those of a previous series, and a reduction in mean vascular volume. The existence of sclerotic lesions and reduction of vascular volume may explain the persistence of pulmonary hypertension, which fresh lesions helped to aggravate. It seems likely that functional and morphologic modifications due to the action of the drug had become self-perpetuating and may finally have induced the fatal outcome in these patients many years after intake of the slimming pill.
对9名在服用食欲抑制剂富马酸氨基苯唑9至17年后死于肺动脉高压疾病的女性患者的肺肌性动脉病变进行了多种方法检查（光学显微镜检查、病变计数、形态计量学）。病变计数显示纤维化和扩张性病变占主导，但也存在活动性病变（内膜增生、丛状病变）。形态计量学显示，与对照组或先前系列研究的动脉相比，中膜平均厚度增加，平均血管容积减少。硬化性病变的存在和血管容积的减少可能解释了肺动脉高压的持续存在，而新出现的病变则加剧了这种情况。由于药物作用导致的功能和形态学改变似乎已经自我延续，最终可能在这些患者服用减肥药多年后导致了致命的后果。
