Institute of Organic Chemistry & MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, Guangdong 510006, P. R. China.
Org Lett. 2023 Jul 14;25(27):5173-5178. doi: 10.1021/acs.orglett.3c01999. Epub 2023 Jun 29.
An efficient and practical route for the synthesis of β-amino sulfides by Lewis acid-mediated electrophilic thiolative difunctionalization of enimides is disclosed. A series of free phenols, electron-rich arene, alcohol, azide, and hydride, are successfully incorporated into the substrates in high regio- and stereoselectivities under mild conditions. The obtained products possess multiple functional groups and can be easily transformed to other valuable molecules.
本文报道了一种通过路易斯酸介导的烯酰胺类化合物的亲电硫代双官能化反应高效、实用的合成β-氨基硫醚的方法。在温和的条件下，一系列游离酚、富电子芳烃、醇、叠氮化物和氢化物可作为底物被高区域和立体选择性地应用于该反应。所得到的产物具有多个官能团，并且可以很容易地转化为其他有价值的分子。
