Andersson M, Page D C, de la Chapelle A
Science. 1986 Aug 15;233(4765):786-8. doi: 10.1126/science.3738510.
Y-chromosomal DNA is present in the genomes of most human XX males. In these cases, maleness is probably due to the presence of the Y-encoded testis-determining factor (TDF). By means of in situ hybridization of a probe (pDP105) detecting Y-specific DNA to metaphases from three XX males, it was demonstrated that the Y DNA is located on the tip of the short arm of an X chromosome. This finding supports the hypothesis that XX maleness is frequently the result of transfer of Y DNA, including TDF, to a paternally derived X chromosome.
大多数人类XX男性的基因组中存在Y染色体DNA。在这些情况下，男性特征可能归因于Y编码的睾丸决定因子（TDF）的存在。通过将检测Y特异性DNA的探针（pDP105）与三名XX男性的中期细胞进行原位杂交，证明Y DNA位于一条X染色体短臂的末端。这一发现支持了这样一种假说，即XX男性特征常常是Y DNA（包括TDF）转移到父源X染色体上的结果。
