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经皮左心耳夹闭术的长期影像学和临床结局。

Long-Term Imaging and Clinical Outcomes of Surgical Left Atrial Appendage Occlusion With AtriClip.

机构信息

Kansas City Heart Rhythm Institute, Overland Park, Kansas.

Midwest Heart and Vascular Specialists, HCA Midwest Health, Overland Park, Kansas.

出版信息

Am J Cardiol. 2023 Aug 15;201:193-199. doi: 10.1016/j.amjcard.2023.06.026. Epub 2023 Jun 27.

DOI:10.1016/j.amjcard.2023.06.026
PMID:37385174
Abstract

Surgical left atrial appendage (LAA) occlusion with an AtriClip (AtriCure, West Chester, Ohio) is frequently performed for stroke prophylaxis in patients with atrial fibrillation (AF). We conducted a retrospective analysis of all patients with long-standing persistent AF who underwent hybrid convergent ablation and LAA clipping. Contrast-enhanced cardiac computed tomography was performed at 3 to 6 months after LAA clipping to assess the degree of complete closure and the residual LAA stump. A total of 78 patients (64 ± 10 years, 72% male) underwent LAA clipping as part of hybrid convergent AF ablation, from 2019 to 2020. Median size of AtriClip used was 45 mm. Mean LA size was 4.6 ± 1 cm. At 3-to-6 months follow-up computed tomography, 46.2% of patients (n = 36) had a residual stump proximal to the deployed LAA clip. Mean depth of residual stump was 3.95 ± 5.5 mm, with 19% of patients (n = 15) having a stump depth of ≥10 mm and 1 patient requiring more endocardial LAA closure owing to large stump depth. During 1-year follow-up, 3 patients developed stroke; device leak of 6 mm was noted in 1 patient; and none of the patients had a thrombus proximal to the clip. In conclusion, high incidence of residual LAA stump was observed with AtriClip. Larger studies with long-term follow-up are needed to better assess the thromboembolic implications of a residual stump after AtriClip placement.

摘要

在心房颤动(AF)患者中,经皮左心耳(LAA)封堵术(AtriCure,俄亥俄州西切斯特)常用于预防中风。我们对所有接受杂交汇聚消融术和 LAA 夹闭术的持续性永久性 AF 患者进行了回顾性分析。LAA 夹闭术后 3 至 6 个月进行增强心脏 CT 检查,以评估完全闭塞程度和残余 LAA 残端。2019 年至 2020 年,共有 78 例患者(64 ± 10 岁,72%为男性)接受了 LAA 夹闭术,作为杂交汇聚 AF 消融术的一部分。使用的 AtriClip 中位尺寸为 45mm。平均左心房大小为 4.6 ± 1cm。在 3 至 6 个月的 CT 随访中,46.2%(n = 36)的患者 LAA 夹闭后近端有残余残端。残余残端的平均深度为 3.95 ± 5.5mm,其中 19%(n = 15)的患者残端深度≥10mm,1 例患者由于残端较大,需要更多的心内膜 LAA 闭合。在 1 年的随访中,有 3 例患者发生中风;1 例患者出现 6mm 器械漏;无患者在夹闭器近端有血栓。总之,AtriClip 夹闭后残余 LAA 残端发生率较高。需要进行更大规模的长期随访研究,以更好地评估 AtriClip 放置后残余残端的血栓栓塞影响。

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引用本文的文献

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J Cardiovasc Dev Dis. 2025 Jul 29;12(8):289. doi: 10.3390/jcdd12080289.
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Long-Term Follow-Up of Left Atrial Appendage Exclusion: Results of the V-CLIP Multi-Center Post-Market Study.左心耳封堵术的长期随访:V-CLIP多中心上市后研究结果
J Clin Med. 2025 Aug 4;14(15):5473. doi: 10.3390/jcm14155473.
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Device-Assisted Left Atrial Appendage Exclusion: From Basic Sciences to Clinical Applications.
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J Cardiovasc Dev Dis. 2024 Oct 18;11(10):332. doi: 10.3390/jcdd11100332.
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Limitations in Contemporary Pharmacological Stroke Prevention Therapies in Atrial Fibrillation: A Descriptive Literature Review.当代房颤药理学卒中预防疗法的局限性:描述性文献综述
J Clin Med. 2023 Oct 18;12(20):6594. doi: 10.3390/jcm12206594.