李斯特菌属水平传播致新生儿致命李斯特菌病凸显新生儿易感性经口感染李斯特菌病。
Fatal neonatal listeriosis following L. monocytogenes horizontal transmission highlights neonatal susceptibility to orally acquired listeriosis.
机构信息
Institut Pasteur, Université Paris Cité, INSERM U1117, Biology of Infection Unit, 75015 Paris, France; Institut Pasteur, National Reference Center and WHO Collaborating Center Listeria, 75015 Paris, France; Cochin University Hospital, Division of Infectious Diseases and Tropical Medicine, APHP, Institut Imagine, 75015 Paris, France.
Groupe Hospitalier Sud Ile-de-France, 77000 Melun, France.
出版信息
Cell Rep Med. 2023 Jul 18;4(7):101094. doi: 10.1016/j.xcrm.2023.101094. Epub 2023 Jun 28.
We report a case of fulminant fatal neonatal listeriosis due to horizontal transmission of Listeria monocytogenes (Lm) in a neonatal double room. Genomic analyses reveal a close genetic relationship between clinical isolates, supporting cross-contamination. Oral inoculation experiments in adult and neonatal mice show that neonates are susceptible to a low Lm inoculum and that this susceptibility results from the immaturity of the neonatal gut microbiota. Infected neonates should therefore be isolated for as long as they shed Lm in their feces to avoid horizontal transmission and its dire consequences.
我们报告了一例新生儿李斯特菌病的暴发性致命病例，这是由于新生儿双人间中李斯特菌（Lm）的水平传播所致。基因组分析显示临床分离株之间存在密切的遗传关系，支持交叉污染。在成年和新生小鼠中的口服接种实验表明，新生小鼠易受低剂量 Lm 的感染，这种易感性是由于新生肠道微生物组的不成熟所致。因此，感染的新生儿应在其粪便中排出 Lm 时进行隔离，以避免水平传播及其严重后果。
Zotero 插件