Department of Chemistry, Preparatory Year Program, Batterjee Medical College, Jeddah, Saudi Arabia; Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt.
Faculty of Dentistry, British University, El Sherouk City, Suez Desert Road, Cairo, 11837, Egypt.
J Ethnopharmacol. 2023 Dec 5;317:116819. doi: 10.1016/j.jep.2023.116819. Epub 2023 Jun 28.
Justicia procumbens L. (JP) (Oriental Water Willow, Shrimp plant, Acanthaceae) is a herbaceous plant that is commonly found in India, Taiwan, Australia, Southern China, Vietnam, and Korea. The plant has been primarily used to treat fever, asthma, edema, cough, jaundice, urinary tract infection, and sore throat, as well as for snake bites and as a fish-killer. In the present review, the reported phyto-chemical, ethno-pharmacological, biological, and toxicological studies on J. procumbens were summarized. Special focus had been given to its reported lignans, regarding their isolation, characterization, quantitative estimation, and biosynthesis.
A survey of the literature was done using assorted databases and publishers; Scopus, Sci-Finder, Web of Science, PubMed, GoogleScholar, ScienceDirect, Wiley, Taylors&Francis, Bentham, Thieme, and Springer.
Currently, 95 metabolites have been separated fromJ. procumbens. Lignans and their glycosides were reported as main phyto-constituents of J. procumbens. Various methods are mentioned for quantitative estimation of these lignans. These phyto-constituents possessed wide pharmacological effectiveness, such as antiplatelet aggregation, antimicrobial, antitumor, and antiviral.
Many of the stated effects are harmonious with the reported traditional uses of this plant. This data could further support J. procumbens's utilization as a herbal remedy and drug lead. However, further study of J. procumbens toxicity, as well as preclinical and clinical investigation is required to ensure the safe usage of J. procumbens.
直立水苏（JP）（东方水柳、虾草、爵床科）是一种草本植物，常见于印度、中国台湾、澳大利亚、中国南方、越南和韩国。该植物主要用于治疗发热、哮喘、水肿、咳嗽、黄疸、尿路感染和喉咙痛，以及蛇咬伤和作为鱼杀手。在本综述中，总结了报道的直立水苏的植物化学、民族药理学、生物学和毒理学研究。特别关注其报道的木脂素，包括它们的分离、表征、定量估计和生物合成。
使用各种数据库和出版商对文献进行了调查；Scopus、Sci-Finder、Web of Science、PubMed、Google Scholar、ScienceDirect、Wiley、Taylors & Francis、Bentham、Thieme 和 Springer。
目前，从 JP 中分离出 95 种代谢物。木脂素及其糖苷被报道为 JP 的主要植物成分。文中提到了各种方法来定量估计这些木脂素。这些植物成分具有广泛的药理作用，如抗血小板聚集、抗菌、抗肿瘤和抗病毒。
许多所述作用与该植物的传统用途相吻合。这些数据可以进一步支持 JP 的作为草药治疗和药物先导的利用。然而，需要进一步研究 JP 的毒性，以及进行临床前和临床研究，以确保 JP 的安全使用。
