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Pharmacological targeting of one‑carbon metabolism as a novel therapeutic strategy for glioblastoma.

作者信息

Sun Yanfei, Mu Guangjing, Xue Zhiwei, Li Xingang, Lin Xiaoying, Han Mingzhi

机构信息

Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University; Jinan Microecological Biomedicine Shandong Laboratory and Shandong Key Laboratory of Brain Function Remodeling, Jinan, China.

The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

出版信息

J Transl Med. 2023 Jun 29;21(1):424. doi: 10.1186/s12967-023-04185-5.

DOI:10.1186/s12967-023-04185-5
PMID:37386497
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10308772/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e14a/10308772/782aea9c3eec/12967_2023_4185_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e14a/10308772/782aea9c3eec/12967_2023_4185_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e14a/10308772/782aea9c3eec/12967_2023_4185_Fig1_HTML.jpg

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本文引用的文献

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Molecular Mechanisms of Drug Resistance in Glioblastoma.胶质母细胞瘤的耐药分子机制。
Int J Mol Sci. 2021 Jun 15;22(12):6385. doi: 10.3390/ijms22126385.
2
Glioma cells require one-carbon metabolism to survive glutamine starvation.神经胶质瘤细胞需要一碳代谢来在谷氨酰胺饥饿中存活。
Acta Neuropathol Commun. 2021 Jan 19;9(1):16. doi: 10.1186/s40478-020-01114-1.
3
Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold.基于结构设计与合成具有三环香豆素骨架的同工酶选择性MTHFD2抑制剂
ACS Med Chem Lett. 2019 May 24;10(6):893-898. doi: 10.1021/acsmedchemlett.9b00069. eCollection 2019 Jun 13.
4
Modulation of Redox Homeostasis by Inhibition of MTHFD2 in Colorectal Cancer: Mechanisms and Therapeutic Implications.抑制 MTHFD2 对结直肠癌氧化还原平衡的调节：机制与治疗意义。
J Natl Cancer Inst. 2019 Jun 1;111(6):584-596. doi: 10.1093/jnci/djy160.
5
Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor.新兴癌症靶点 MTHFD2 与其基于底物的抑制剂复合物的晶体结构。
Cancer Res. 2017 Feb 15;77(4):937-948. doi: 10.1158/0008-5472.CAN-16-1476. Epub 2016 Nov 29.