The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, 523808, China.
Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs, and School of Pharmacy, Guangdong Medical University, Guangdong Medical University Key Laboratory of Research and Development of New Medical Materials, Dongguan, 523808, China.
J Mater Chem B. 2023 Jul 26;11(29):6802-6822. doi: 10.1039/d3tb00505d.
The detection of active substances in the body is very important for good human health as it gives important insights into the smooth functioning of the body. Most of the conventional materials that can be used as suitable probes require complicated fabrication methodologies, have poor stability and are susceptible to environmental effects. In contrast, metal-organic frameworks (MOFs) offer unique advantages as probes for testing analytes due to their tunable porosity, good specific surface area and ease of modification. Unlike previously reported perspectives/reviews, this perspective focuses on the latest applications of MOFs as detection materials for hydrogen peroxide, various metal ions, hydrogen sulfide, organic small molecules, glutathione, and organic macromolecules such as nucleic acids, and focuses on providing a more detailed mechanism of action. Also, the basic principles of action utilized by this class of materials are discussed.
体内活性物质的检测对于人类健康非常重要，因为它可以深入了解身体的正常运转。大多数可作为合适探针使用的常规材料都需要复杂的制造方法，稳定性差，并且容易受到环境影响。相比之下，金属有机骨架（MOFs）由于其可调节的孔隙率、良好的比表面积和易于修饰的特性，作为测试分析物的探针具有独特的优势。与之前报道的观点/综述不同，本观点侧重于 MOFs 作为检测材料在过氧化氢、各种金属离子、硫化氢、有机小分子、谷胱甘肽以及核酸等有机大分子中的最新应用，并侧重于提供更详细的作用机制。此外，还讨论了这类材料所利用的基本作用原理。
